Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | METAP2 | P50579 | 2/20 | 0.33 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18446041 | 0.79 | MAPT (0.38) | MAPTHSD17B10HPGDALOX15RECQL | |
| SCHEMBL31165845 | 0.76 | ALDH1A1 (0.33) | MAPTHSD17B10PDPK1KDM4EALDH1A1 | |
| SCHEMBL25833188 | 0.73 | GABRA1 (0.38) | HPGDTSHRCA1CA2LMNA | |
| SCHEMBL3402475 | 0.73 | KCNA5 (0.48) | MAPTHSD17B10HPGDALOX15RECQL | |
| SCHEMBL25667844 | 0.67 | — | — | |
| SCHEMBL3875204 | 0.66 | HPGD (0.52) | MAPTHSD17B10TRPA1HPGDALOX15 | |
| SCHEMBL12329 | 0.66 | MAPT (0.56) | MAPTHSD17B10KDM4EALDH1A1 | |
| SCHEMBL28481670 | 0.65 | TRPA1 (0.41) | MAPTHSD17B10TRPA1HPGDALOX15 | |
| SCHEMBL2977917 | 0.64 | ALDH1A1 (0.35) | MAPTHSD17B10KDM4EALDH1A1LMNA | |
| SCHEMBL13764538 | 0.63 | NOS2 (0.41) | MAPTHSD17B10KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015164956-A1 | BENZISOTHIAZOLE DERIVATIVE COMPOUNDS AS THERAPEUTICS AND METHODS FOR THEIR USE | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2015-11-05 | — | — | WO | disclosed |