Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.31 |
| ▸ | LDHB | P07195 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL59948 | 1.00 | TDP1 (0.50) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL11058354 | 0.96 | TDP1 (0.47) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL11058360 | 0.96 | TDP1 (0.47) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL3207375 | 0.96 | TDP1 (0.47) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL28292654 | 0.96 | TDP1 (0.47) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL15043 | 0.96 | TDP1 (0.53) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL15005463 | 0.96 | TDP1 (0.53) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL11235035 | 0.96 | TDP1 (0.53) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL491341 | 0.96 | TDP1 (0.53) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL182989 | 0.96 | TDP1 (0.53) | TDP1FFAR3LCKFYNALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2467092-B1 | HYBRID POLYMER NETWORK COMPOSITIONS FOR USE IN DENTAL APPLICATIONS | DENTSPLY SIRONA INC (US) | 2019-08-28 | — | — | EP | claimed |
| US-8222315-B2 | Method for producing composites that can be used in dentistry | IVOCLAR VIVADENT AG (LI) | 2012-07-17 | — | — | US | claimed |
| EP-1945178-B1 | METHOD FOR PRODUCING COMPOSITES THAT CAN BE USED IN DENTISTRY | IVOCLAR VIVADENT AG (LI) | 2012-01-11 | — | — | EP | claimed |
| US-20090234044-A1 | Method for Producing Composites That Can Be Used in Dentistry | IVOCLAR VIVADENT AG (LI) | 2009-09-17 | — | — | US | claimed |
| EP-0547126-B1 | BIODEGRADABLE POLYMERS CONTAINING DIESTER UNITS | NYCOMED IMAGING AS (NO) | 1996-02-28 | — | — | EP | claimed |
| US-8222315-B2 | Method for producing composites that can be used in dentistry | IVOCLAR VIVADENT AG (LI) | 2012-07-17 | — | — | US | disclosed |
| US-7855242-B2 | Dental resin composition, method of manufacture, and method of use thereof | PENTRON CLINICAL TECHNOLOGIES LLC (US) | 2010-12-21 | — | — | US | disclosed |
| US-7659324-B2 | Accelerators and initiators, both with polymerizable groups, can be cured without problems by radical polymerization, materials being obtained which contain an extremely small proportion of soluble components | IVOCLAR VIVADENT AG (LI) | 2010-02-09 | — | — | US | disclosed |
| US-20090234044-A1 | Method for Producing Composites That Can Be Used in Dentistry | IVOCLAR VIVADENT AG (LI) | 2009-09-17 | — | — | US | disclosed |
| CN-100338110-C | Organoborane amine complex polymerization initiators and polymerizable compositions | DOW GLOBAL TECHNOLOGIES INC (US) | 2007-09-19 | — | — | CN | disclosed |
| US-20070049656-A1 | DENTAL RESIN COMPOSITION, METHOD OF MANUFACTURE, AND METHOD OF USE THEREOF | PENTRON CLINICAL TECHNOLOGIES, INC (US) | 2007-03-01 | — | — | US | disclosed |
| US-20060051109-A1 | Method and apparatus for manufacturing 3D image display | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2006-03-09 | — | — | US | disclosed |
| US-5823373-A | FOR USE IN COVERING A MOUTH PART OF A CONTAINER FOR A MEDICAMENT | DAIKYO SEIKO, LTD. (JP) | 1998-10-20 | — | — | US | disclosed |
| EP-0853939-A2 | Dental resin materials | JENERIC/PENTRON Incorporated (US) | 1998-07-22 | — | — | EP | disclosed |
| EP-0819617-A1 | A plastic cap and a process for the production of the same | DAIKYO SEIKO, LTD. (JP) | 1998-01-21 | — | — | EP | disclosed |
| WO-1997042530-A1 | REFRACTIVE INDEX GRADIENT LENS | INNOTECH, INC. (US) | 1997-11-13 | — | — | WO | disclosed |
| EP-0769456-A2 | A plastic cap and a process for the production of the same | DAIKYO SEIKO, LTD. (JP) | 1997-04-23 | — | — | EP | disclosed |
| US-5444104-A | Dental restorative material based on a polycarbonate dimethacrylate | JENERIC/PENTRON, INC. (US) | 1995-08-22 | — | — | US | disclosed |
| US-5276068-A | Dimethacrylate compounds containing carbonate groups, adhesives, restoration material | JENERIC/PENTRON, INC. (US) | 1994-01-04 | — | — | US | disclosed |
| US-4107386-A | Anaerobically hardening adhesives and sealants based on (meth)acrylic esters containing polycarbonates terminated by (meth)acrylic ester groups | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1978-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049656-A1 | DENTAL RESIN COMPOSITION, METHOD OF MANUFACTURE, AND METHOD OF USE THEREOF | CAD, MMAB, DNMT3A | TDP1 1326/4885FFAR3 2385/4885LCK 4536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.