Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | GRK6 | P43250 | 1/20 | 0.43 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | CCKAR | P32238 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1725504 | 0.90 | KMO (0.51) | PIM1PIK3CAPIM2 | |
| SCHEMBL1723609 | 0.79 | IRAK4 (0.48) | KMT2AMEN1ALDH1A1PIM1CNR1 | |
| SCHEMBL13187192 | 0.79 | NPC1 (0.50) | KDM4EKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9907329 | 0.78 | KDM4E (0.62) | KDM4EKMT2AMEN1PIM1MMP2 | |
| SCHEMBL1721889 | 0.73 | KMO (0.52) | KDM4EKMT2AMEN1ALDH1A1CNR2 | |
| SCHEMBL1724445 | 0.73 | KDM4E (0.49) | KDM4EKMT2AMEN1MMP2TSHR | |
| SCHEMBL17420285 | 0.72 | TERT (0.60) | KDM4EKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL1721891 | 0.71 | IRAK4 (0.51) | KMT2AMEN1PIK3CA | |
| SCHEMBL1726582 | 0.70 | CYP11B1 (0.47) | KDM4EKMT2APIM1PIK3CAPIM2 | |
| SCHEMBL17420335 | 0.69 | TERT (0.56) | KDM4EKMT2AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403833-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101949-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010101949-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-09-10 | — | — | WO | disclosed |