Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.45 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 5/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17672270 | 0.78 | PLA2G2A (0.59) | IDH1MEP1BPARP1F10PRSS1 | |
| SCHEMBL29991111 | 0.74 | FYN (0.46) | FYNKCNH2 | |
| SCHEMBL27892808 | 0.73 | VNN1 (0.50) | FYNIDH1MEP1BPARP1VNN1 | |
| SCHEMBL4224616 | 0.73 | PLA2G2A (0.69) | IDH1ENPP2MEP1BPARP1PRSS1 | |
| SCHEMBL2733048 | 0.71 | ENPP2 (0.48) | FYNIDH1ENPP2MEP1BPARP1 | |
| SCHEMBL27550934 | 0.71 | CYP17A1 (0.61) | IDH1ENPP2MEP1BPARP1PRSS1 | |
| SCHEMBL30839554 | 0.71 | KDM4C (0.40) | PARP1GPR142 | |
| SCHEMBL28174046 | 0.70 | VNN1 (0.54) | IDH1MEP1BPARP1VNN1AURKA | |
| SCHEMBL31557871 | 0.69 | PLA2G2A (0.58) | IDH1ENPP2MEP1BPARP1PRSS1 | |
| SCHEMBL509423 | 0.69 | LOXL2 (0.66) | IDH1ENPP2MEP1BPARP1FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403835-A1 | NOVEL PHENYL IMIDAZOLES AND PHENYL TRIAZOLES AS GAMMA-SECRETASE MODULATORS | Pfizer Inc. (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010100606-A1 | NOVEL PHENYL IMIDAZOLES AND PHENYL TRIAZOLES AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2010-09-10 | — | — | WO | disclosed |