Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 3/20 | 0.53 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL939732 | 0.83 | ALDH1A1 (0.52) | CDC7DBF4CDK5CDK5R1ALDH1A1 | |
| SCHEMBL256755 | 0.80 | GABRP (0.56) | CDC7DBF4LMNACYP1A2CYP3A4 | |
| SCHEMBL16065124 | 0.80 | GSK3B (0.37) | CDC7DBF4CDK5CDK5R1ALDH1A1 | |
| SCHEMBL938199 | 0.79 | HPGD (0.55) | ALDH1A1HSD17B10HPGDLMNAMAPT | |
| Hydrochloric Acid SCHEMBL5591077 | 0.79 | JMJD6 (0.55) | CDC7DBF4LMNACYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL6740832 | 0.79 | JMJD6 (0.55) | CDC7DBF4LMNACYP1A2CYP3A4 | |
| SCHEMBL1724052 | 0.79 | GABRP (0.59) | CDC7DBF4ALDH1A1MKNK1MKNK2 | |
| SCHEMBL5237356 | 0.77 | MAPT (0.56) | ALDH1A1HPGDMAPTRAB9AMEN1 | |
| SCHEMBL9454728 | 0.77 | HSD17B10 (0.53) | CDC7DBF4ALDH1A1HSD17B10HPGD | |
| SCHEMBL31704904 | 0.77 | CYP2C9 (0.47) | CDC7DBF4ALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403857-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101302-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-10 | — | — | WO | disclosed |