Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | UGCG | Q16739 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL172381 | 0.90 | MTNR1B (0.62) | MTNR1AMTNR1BKMT2ATSHREED | |
| SCHEMBL128044 | 0.87 | MTNR1A (0.51) | MTNR1AMTNR1BKMT2AALDH1A1LMNA | |
| SCHEMBL124654 | 0.81 | MTNR1A (0.53) | MTNR1AMTNR1BMAPK14EED | |
| SCHEMBL172456 | 0.78 | MTNR1B (0.60) | MTNR1AMTNR1BKMT2AL3MBTL1 | |
| SCHEMBL125589 | 0.78 | MTNR1A (0.63) | MTNR1AMTNR1BKMT2AALDH1A1LMNA | |
| SCHEMBL126984 | 0.77 | MTNR1B (0.82) | MTNR1AMTNR1B | |
| SCHEMBL172421 | 0.77 | MTNR1A (0.54) | MTNR1AMTNR1BMAPK14EED | |
| Hydrochloric Acid SCHEMBL130262 | 0.76 | MTNR1A (0.53) | MTNR1AMTNR1BMAPK14EED | |
| SCHEMBL124932 | 0.76 | MTNR1A (0.48) | MTNR1AMTNR1BMAPK14EED | |
| SCHEMBL126117 | 0.76 | MTNR1B (0.71) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100895-B1 | TRICYCLIC COMPOUND AND MEDICAL USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-03-07 | — | — | EP | disclosed |