Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 12/20 | 0.62 |
| ▸ | MTNR1A | P48039 | 11/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL172491 | 0.90 | MTNR1A (0.52) | MTNR1BMTNR1AKMT2ATSHREED | |
| SCHEMBL125589 | 0.88 | MTNR1A (0.63) | MTNR1BMTNR1AMEN1KMT2AEGFR | |
| SCHEMBL127599 | 0.81 | MTNR1A (0.67) | MTNR1BMTNR1AEED | |
| SCHEMBL172456 | 0.81 | MTNR1B (0.60) | MTNR1BMTNR1AMEN1KMT2ACYP1A2 | |
| SCHEMBL172399 | 0.78 | MTNR1A (0.67) | MTNR1BMTNR1A | |
| SCHEMBL172150 | 0.78 | MTNR1B (0.63) | MTNR1BMTNR1A | |
| SCHEMBL123755 | 0.77 | MTNR1B (1.00) | MTNR1BMTNR1A | |
| SCHEMBL172472 | 0.77 | MTNR1A (0.67) | MTNR1BMTNR1AEED | |
| SCHEMBL128044 | 0.77 | MTNR1A (0.51) | MTNR1BMTNR1AMEN1KMT2A | |
| SCHEMBL126045 | 0.76 | MTNR1A (0.60) | MTNR1BMTNR1AMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100895-B1 | TRICYCLIC COMPOUND AND MEDICAL USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-03-07 | — | — | EP | disclosed |