Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 13/20 | 0.60 |
| ▸ | MTNR1A | P48039 | 12/20 | 0.60 |
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL125340 | 0.84 | MTNR1A (0.58) | MTNR1BMTNR1A | |
| SCHEMBL172150 | 0.84 | MTNR1B (0.63) | MTNR1BMTNR1A | |
| SCHEMBL172381 | 0.81 | MTNR1B (0.62) | MTNR1BMTNR1ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL172399 | 0.81 | MTNR1A (0.67) | MTNR1BMTNR1A | |
| SCHEMBL126960 | 0.78 | MTNR1B (0.65) | MTNR1BMTNR1A | |
| SCHEMBL172491 | 0.78 | MTNR1A (0.52) | MTNR1BMTNR1AL3MBTL1KMT2A | |
| SCHEMBL127145 | 0.76 | MTNR1B (0.66) | MTNR1BMTNR1A | |
| SCHEMBL128531 | 0.75 | MTNR1A (0.59) | MTNR1BMTNR1A | |
| SCHEMBL126690 | 0.75 | MTNR1A (1.00) | MTNR1BMTNR1A | |
| SCHEMBL125589 | 0.74 | MTNR1A (0.63) | MTNR1BMTNR1ACYP2C9CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100895-B1 | TRICYCLIC COMPOUND AND MEDICAL USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2012-03-07 | — | — | EP | disclosed |