SCHEMBL17249529

SCHEMBL17249529

Clc1ccccc1Nc1nc2nonc2nc1Nc1ccccc1Cl

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.49
MAPT P10636 4/20 0.47
TP53 P04637 3/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
IGF1R P08069 1/20 0.46
PDE5A O76074 1/20 0.45
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
LMNA P02545 1/20 0.45
ADRA2A P08913 1/20 0.44
ADRA2B P18089 1/20 0.44
ADRA2C P18825 1/20 0.44
KMT2A Q03164 4/20 0.42
KDM4E B2RXH2 2/20 0.42
AURKA O14965 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TTBK1 Q5TCY1 1/20 0.42
TTBK2 Q6IQ55 1/20 0.42
POLB P06746 2/20 0.42
ALDH1A1 P00352 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3060967 0.89 MAPT (0.56) TSHRMAPTTP53SMN1; SMN2IGF1R
SCHEMBL21499859 0.89 NPC1 (0.43) TSHRMAPTTP53SMN1; SMN2IGF1R
SCHEMBL3055713 0.87 MAPT (0.50) TSHRMAPTTP53SMN1; SMN2IGF1R
SCHEMBL20570269 0.80 TP53 (0.67) MAPTTP53SMN1; SMN2LMNAADRA2A
SCHEMBL3063373 0.79 MAPT (0.46) MAPTTP53SMN1; SMN2NPC1RAB9A
SCHEMBL29774507 0.79 SMN1; SMN2 (0.47) TSHRMAPTTP53SMN1; SMN2NPC1
SCHEMBL17249535 0.79 TP53 (0.47) MAPTTP53SMN1; SMN2LMNAKMT2A
SCHEMBL17240563 0.79 SMN1; SMN2 (0.47) TSHRMAPTTP53SMN1; SMN2NPC1
SCHEMBL17249532 0.79 MAPT (0.47) TSHRMAPTTP53SMN1; SMN2LMNA
SCHEMBL20569973 0.75 ALDH1A1 (0.69) MAPTTP53SMN1; SMN2NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3630115-B1 COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS UNIV VIRGINIA PATENT FOUNDATION (US) 2025-12-10 EP disclosed
US-11896591-B2 Compositions and methods for preparing and using mitochondrial uncouplers UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2024-02-13 US disclosed
US-20220017537-A1 COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTATSIS AND INSULIN ACTION UNIV VIRGINIA PATENT FOUNDATION (US) 2022-01-20 US disclosed
US-11066415-B2 Compositions and methods for regulating glucose homeostasis and insulin action UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2021-07-20 US disclosed
US-20200369683-A1 COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTASIS AND INSULIN ACTION UNIVERSITY OF VIRGINIA 2020-11-26 US disclosed
US-20200323846-A1 COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS UNIVERSITY OF VIRGINA PATENT FOUNDATION (US) 2020-10-15 US disclosed
US-10683306-B2 Compositions and methods of regulating glucose homeostasis and insulin action UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2020-06-16 US disclosed
EP-3630115-A1 COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS University Of Virginia Patent Foundation (US) 2020-04-08 EP disclosed
US-10479800-B2 Compositions and methods for regulating glucose homeostasis and insulin action UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2019-11-19 US disclosed
US-20190330232-A1 COMPOSITIONS AND METHODS OF REGULATING GLUCOSE HOMEOSTASIS AND INSULIN ACTION UNIVERSITY OF VIRGINIA 2019-10-31 US disclosed
WO-2018217757-A1 COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2018-11-29 WO disclosed
US-20170240563-A1 COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTASIS AND INSULIN ACTION UNIVERSITY OF VIRGINIA 2017-08-24 US disclosed
US-20170240563-A1 COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTASIS AND INSULIN ACTION UNIVERSITY OF VIRGINIA 2017-08-24 US disclosed
US-9492448-B2 Compositions and methods for regulating glucose homeostasis and insulin action UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2016-11-15 US disclosed
US-9492448-B2 Compositions and methods for regulating glucose homeostasis and insulin action UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2016-11-15 US disclosed
US-20150322081-A1 COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTASIS AND INSULIN ACTION UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2015-11-12 US disclosed
US-20150322081-A1 COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTASIS AND INSULIN ACTION UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2015-11-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170240563-A1 COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTASIS AND INSULIN ACTION GPR119, GLS, IRS1 TSHR 3693/4885MAPT 4551/4885TP53 3917/4885
US-11066415-B2 Compositions and methods for regulating glucose homeostasis and insulin action GPR119, GLS, IRS1 TSHR 3693/4885MAPT 4551/4885TP53 3917/4885
US-20200369683-A1 COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTASIS AND INSULIN ACTION GPR119, GLS, IRS1 TSHR 3693/4885MAPT 4551/4885TP53 3917/4885
US-10683306-B2 Compositions and methods of regulating glucose homeostasis and insulin action GPR119, GLS, IRS1 TSHR 3595/4885MAPT 4531/4885TP53 3965/4885
US-20190330232-A1 COMPOSITIONS AND METHODS OF REGULATING GLUCOSE HOMEOSTASIS AND INSULIN ACTION GPR119, GLS, IRS1 TSHR 3595/4885MAPT 4531/4885TP53 3965/4885
US-10479800-B2 Compositions and methods for regulating glucose homeostasis and insulin action GPR119, GLS, IRS1 TSHR 3693/4885MAPT 4551/4885TP53 3917/4885
US-11896591-B2 Compositions and methods for preparing and using mitochondrial uncouplers ACAD9, GPR119, NDUFAF1 TSHR 1437/4885MAPT 3834/4885TP53 3537/4885
US-20150322081-A1 COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTASIS AND INSULIN ACTION GPR119, GLS, IRS1 TSHR 3693/4885MAPT 4551/4885TP53 3917/4885
US-20200323846-A1 COMPOSITIONS AND METHODS FOR PREPARING AND USING MITOCHONDRIAL UNCOUPLERS ACAD9, GPR119, NDUFAF1 TSHR 1437/4885MAPT 3834/4885TP53 3537/4885
US-20220017537-A1 COMPOSITIONS AND METHODS FOR REGULATING GLUCOSE HOMEOSTATSIS AND INSULIN ACTION GPR119, GLS, IRS1 TSHR 3659/4885MAPT 4609/4885TP53 4255/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.