Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 14/20 | 0.39 |
| ▸ | GBA1 | P04062 | 4/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17239509 | 0.85 | CYP19A1 (0.32) | CYP19A1HSP90AB1 | |
| SCHEMBL17251607 | 0.85 | CYP19A1 (0.33) | CYP19A1HSP90AB1 | |
| SCHEMBL17249575 | 0.80 | NOTUM (0.44) | CYP19A1GBA1HSP90AB1 | |
| SCHEMBL17249572 | 0.77 | CYP19A1 (0.41) | CYP19A1GBA1 | |
| SCHEMBL17249574 | 0.72 | GBA1 (0.36) | CYP19A1GBA1HSP90AB1 | |
| SCHEMBL25623211 | 0.71 | HSP90AB1 (0.35) | CYP19A1GBA1HSP90AB1 | |
| SCHEMBL17878164 | 0.71 | GBA1 (0.35) | GBA1 | |
| SCHEMBL26879503 | 0.69 | CYP19A1 (0.53) | CYP19A1GBA1 | |
| SCHEMBL20805927 | 0.68 | P2RX7 (0.37) | CYP19A1GBA1HSP90AB1 | |
| SCHEMBL12033359 | 0.68 | GBA1 (0.49) | CYP19A1GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9328096-B2 | Tropomyosin-related kinase inhibitors | PFIZER INC. (US) | 2016-05-03 | — | — | US | disclosed |
| US-9328096-B2 | Tropomyosin-related kinase inhibitors | PFIZER INC. (US) | 2016-05-03 | — | — | US | disclosed |
| US-20150322043-A1 | TROPOMYOSIN-RELATED KINASE INHIBITORS | PFIZER (US) | 2015-11-12 | — | — | US | disclosed |
| US-20150322043-A1 | TROPOMYOSIN-RELATED KINASE INHIBITORS | PFIZER (US) | 2015-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150322043-A1 | TROPOMYOSIN-RELATED KINASE INHIBITORS | TPM3, MUSK, TPM4 | CYP19A1 3639/4885GBA1 4032/4885HSP90AB1 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.