Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17239536 | 0.86 | HSP90AB1 (0.34) | HSP90AB1LOXL2 | |
| SCHEMBL17251609 | 0.82 | HSP90AB1 (0.33) | HSP90AB1LOXL2 | |
| SCHEMBL18606371 | 0.78 | LOXL2 (0.38) | HSP90AB1LOXL2CYP19A1 | |
| SCHEMBL17249575 | 0.76 | NOTUM (0.44) | GBA1HSP90AB1CYP19A1 | |
| SCHEMBL17249572 | 0.74 | CYP19A1 (0.41) | GBA1CYP19A1 | |
| SCHEMBL17249573 | 0.72 | CYP19A1 (0.39) | GBA1HSP90AB1CYP19A1 | |
| SCHEMBL18224567 | 0.72 | DDB1 (0.36) | HSP90AB1LOXL2 | |
| SCHEMBL17614444 | 0.71 | MMP9 (0.34) | GBA1HSP90AB1 | |
| SCHEMBL17963226 | 0.70 | CYP19A1 (0.61) | HSP90AB1CYP19A1 | |
| SCHEMBL20805924 | 0.68 | P2RX7 (0.41) | HSP90AB1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9328096-B2 | Tropomyosin-related kinase inhibitors | PFIZER INC. (US) | 2016-05-03 | — | — | US | disclosed |
| US-9328096-B2 | Tropomyosin-related kinase inhibitors | PFIZER INC. (US) | 2016-05-03 | — | — | US | disclosed |
| US-20150322043-A1 | TROPOMYOSIN-RELATED KINASE INHIBITORS | PFIZER (US) | 2015-11-12 | — | — | US | disclosed |
| US-20150322043-A1 | TROPOMYOSIN-RELATED KINASE INHIBITORS | PFIZER (US) | 2015-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150322043-A1 | TROPOMYOSIN-RELATED KINASE INHIBITORS | TPM3, MUSK, TPM4 | GBA1 4032/4885HSP90AB1 344/4885LOXL2 3494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.