Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365852 | 0.90 | CYP3A4 (0.39) | ALDH1A1CYP3A4ALOX15TSHRTDP1 | |
| SCHEMBL16761022 | 0.90 | ALDH1A1 (0.42) | ALDH1A1CYP3A4ALOX15TSHRTDP1 | |
| SCHEMBL16761024 | 0.81 | CYP3A4 (0.41) | ALDH1A1CYP3A4TSHRCYP2C9CYP2C19 | |
| SCHEMBL17228535 | 0.76 | TSHR (0.42) | CYP3A4TSHRTDP1CYP2C9CYP2C19 | |
| SCHEMBL10987006 | 0.76 | ALDH1A1 (0.34) | ALDH1A1CYP3A4ALOX15TSHRTDP1 | |
| SCHEMBL9067967 | 0.74 | ALDH1A1 (0.41) | ALDH1A1CYP3A4ALOX15TSHRTDP1 | |
| SCHEMBL8803824 | 0.74 | CYP2D6 (0.41) | ALDH1A1CYP3A4ALOX15TSHRTDP1 | |
| SCHEMBL9468717 | 0.74 | CYP2D6 (0.44) | ALDH1A1CYP3A4ALOX15TSHRTDP1 | |
| SCHEMBL13469072 | 0.74 | ACHE (0.38) | ALDH1A1CYP3A4TSHRCYP2C9CYP2C19 | |
| SCHEMBL16761019 | 0.74 | TSHR (0.37) | CYP3A4TSHRTDP1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9464081-B2 | Pyrrolidine derivatives and their use as complement pathway modulators | NOVARTIS AG (CH) | 2016-10-11 | — | — | US | disclosed |
| US-9464081-B2 | Pyrrolidine derivatives and their use as complement pathway modulators | NOVARTIS AG (CH) | 2016-10-11 | — | — | US | disclosed |
| US-20150322060-A1 | PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS | NOVARTIS AG (CH) | 2015-11-12 | — | — | US | disclosed |
| US-20150322060-A1 | PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS | NOVARTIS AG (CH) | 2015-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150322060-A1 | PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS | CFD, TFPI, CFB | ALDH1A1 2685/4885CYP3A4 1520/4885ALOX15 439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.