Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | HKDC1 | Q2TB90 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | S100A4 | P26447 | 6/20 | 0.51 |
| ▸ | CDC25B | P30305 | 10/20 | 0.50 |
| ▸ | CDC25A | P30304 | 8/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.50 |
| ▸ | MAP2K7 | O14733 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17249922 | 0.83 | HKDC1 (0.50) | MAPTTDP1ALDH1A1LMNAPOLB | |
| SCHEMBL17249963 | 0.81 | MAPT (0.56) | MAPTTDP1ALDH1A1LMNAMITF | |
| SCHEMBL17249978 | 0.81 | CDC25A (0.59) | MAPTTDP1ALDH1A1LMNAHTT | |
| SCHEMBL10502055 | 0.78 | MAPT (0.70) | MAPTTDP1ALDH1A1LMNAPOLB | |
| SCHEMBL17250098 | 0.78 | MAPT (0.56) | MAPTTDP1ALDH1A1LMNAMITF | |
| SCHEMBL9713854 | 0.74 | HKDC1 (0.65) | MAPTTDP1HKDC1MEN1KMT2A | |
| SCHEMBL17250422 | 0.73 | HKDC1 (0.56) | MAPTTDP1ALDH1A1LMNAHTT | |
| SCHEMBL17249965 | 0.73 | MAPT (1.00) | MAPTTDP1ALDH1A1LMNAMITF | |
| SCHEMBL17242653 | 0.72 | HKDC1 (0.49) | MAPTTDP1HKDC1MEN1KMT2A | |
| SCHEMBL17249972 | 0.71 | S100A4 (0.45) | MAPTTDP1ALDH1A1LMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015172076-A1 | NAPHTHAQUINONE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2015-11-12 | — | — | WO | disclosed |