Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.56 |
| ▸ | MEN1 | O00255 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 7/20 | 0.56 |
| ▸ | HTT | P42858 | 7/20 | 0.56 |
| ▸ | LMNA | P02545 | 6/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.56 |
| ▸ | MITF | O75030 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | ATM | Q13315 | 2/20 | 0.56 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HKDC1 | Q2TB90 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502055 | 0.82 | MAPT (0.70) | MAPTKMT2AMEN1NPC1HTT | |
| SCHEMBL17249963 | 0.82 | MAPT (0.56) | MAPTKMT2AMEN1NPC1HTT | |
| SCHEMBL7912341 | 0.80 | MAPT (0.73) | MAPTKMT2AMEN1NPC1HTT | |
| SCHEMBL17249970 | 0.78 | MAPT (0.57) | MAPTKMT2AMEN1NPC1HTT | |
| SCHEMBL17249922 | 0.77 | HKDC1 (0.50) | MAPTKMT2AMEN1NPC1HTT | |
| SCHEMBL17249978 | 0.76 | CDC25A (0.59) | MAPTKMT2AMEN1NPC1HTT | |
| SCHEMBL17249972 | 0.74 | S100A4 (0.45) | MAPTKMT2AMEN1NPC1HTT | |
| SCHEMBL17250512 | 0.74 | IDO1 (0.56) | MAPTKMT2AMEN1NPC1HTT | |
| SCHEMBL9713854 | 0.74 | HKDC1 (0.65) | MAPTKMT2AMEN1MAPK1NPSR1 | |
| Anthraquinone SCHEMBL28378374 | 0.74 | MEN1 (0.63) | MAPTKMT2AMEN1NPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015172076-A1 | NAPHTHAQUINONE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2015-11-12 | — | — | WO | disclosed |