Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | HKDC1 | Q2TB90 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | CDC25B | P30305 | 4/20 | 0.51 |
| ▸ | CDC25A | P30304 | 3/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10502055 | 0.84 | MAPT (0.70) | MAPTNPSR1HKDC1TDP1MEN1 | |
| SCHEMBL5497788 | 0.77 | MAPT (0.65) | MAPTNPSR1HKDC1TDP1MEN1 | |
| SCHEMBL9713854 | 0.76 | HKDC1 (0.65) | MAPTNPSR1HKDC1TDP1MEN1 | |
| SCHEMBL17250512 | 0.76 | IDO1 (0.56) | MAPTNPSR1HKDC1TDP1MEN1 | |
| SCHEMBL740371 | 0.73 | FGFR1 (0.61) | MAPTNPSR1HKDC1TDP1MEN1 | |
| SCHEMBL17250098 | 0.73 | MAPT (0.56) | MAPTNPSR1HKDC1TDP1MEN1 | |
| SCHEMBL17249963 | 0.73 | MAPT (0.56) | MAPTNPSR1HKDC1TDP1MEN1 | |
| SCHEMBL14232080 | 0.72 | CDC25A (0.67) | MAPTNPSR1HKDC1TDP1MEN1 | |
| SCHEMBL17250100 | 0.71 | HKDC1 (0.79) | MAPTNPSR1HKDC1TDP1MEN1 | |
| SCHEMBL17250420 | 0.70 | MAPK1 (0.50) | MAPTNPSR1HKDC1TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015172076-A1 | NAPHTHAQUINONE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2015-11-12 | — | — | WO | disclosed |