Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ASPH | Q12797 | 1/20 | 0.34 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.34 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20105148 | 1.00 | SLC6A4 (0.39) | SLC6A4SLC6A2MEN1KMT2AMARK3 | |
| SCHEMBL17254694 | 0.87 | HTT (0.38) | SLC6A4SLC6A2MEN1KMT2ACYP3A4 | |
| SCHEMBL20105192 | 0.87 | HTT (0.38) | SLC6A4SLC6A2MEN1KMT2ACYP3A4 | |
| SCHEMBL17254680 | 0.86 | MEN1 (0.38) | SLC6A4SLC6A2MEN1KMT2ACYP3A4 | |
| SCHEMBL20105231 | 0.86 | MEN1 (0.38) | SLC6A4SLC6A2MEN1KMT2ACYP3A4 | |
| SCHEMBL21217885 | 0.86 | SLC6A4 (0.41) | SLC6A4SLC6A2MEN1KMT2AMARK3 | |
| SCHEMBL20105186 | 0.84 | BRD4 (0.42) | SLC6A4SLC6A2MEN1KMT2AMARK3 | |
| SCHEMBL17254695 | 0.84 | BRD4 (0.42) | SLC6A4SLC6A2MEN1KMT2AMARK3 | |
| SCHEMBL17254668 | 0.82 | CRHBP (0.55) | KMT2ACRHBPCRHR2SMN1; SMN2HTT | |
| SCHEMBL16707142 | 0.77 | BRD4 (0.40) | SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210038602-A1 | COMBINATION TREATMENT OF ACUTE MYELOID LEUKEMIA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-02-11 | — | — | US | disclosed |
| EP-3140304-B1 | BENZIMIDAZOLE DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2018-05-02 | — | — | EP | disclosed |
| US-9428515-B2 | Benzimidazole derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-08-30 | — | — | US | disclosed |
| US-9428515-B2 | Benzimidazole derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-08-30 | — | — | US | disclosed |
| US-20150322073-A1 | Benzimidazole Derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-11-12 | — | — | US | disclosed |
| US-20150322073-A1 | Benzimidazole Derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-11-12 | — | — | US | disclosed |
| WO-2015169962-A1 | BENZIMIDAZOLE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210038602-A1 | COMBINATION TREATMENT OF ACUTE MYELOID LEUKEMIA | BRD4, MCL1, BET1 | SLC6A4 2122/4885SLC6A2 2618/4885MEN1 1281/4885 |
| US-20150322073-A1 | Benzimidazole Derivatives | MKI67, CCNI, CCND1 | SLC6A4 2948/4885SLC6A2 3521/4885MEN1 1650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.