Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2052349 | 0.93 | KDM4E (0.67) | KDM4EGAAADORA2AL3MBTL1MEN1 | |
| Phenol SCHEMBL4337822 | 0.80 | KDM4E (0.58) | KDM4EGAAL3MBTL1MEN1KMT2A | |
| SCHEMBL17255679 | 0.80 | KDM4E (0.62) | KDM4EGAAADORA2AL3MBTL1MEN1 | |
| SCHEMBL17255733 | 0.80 | KDM4E (0.47) | KDM4EGAAADORA2AL3MBTL1MEN1 | |
| SCHEMBL15442122 | 0.78 | MYC (0.60) | KDM4EGAAL3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4336655 | 0.77 | KDM4E (0.64) | KDM4EGAAL3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4336653 | 0.77 | KDM4E (0.64) | KDM4EGAAL3MBTL1MEN1KMT2A | |
| SCHEMBL17255718 | 0.75 | GAA (0.55) | KDM4EGAAADORA2ACYP3A4ADORA1 | |
| SCHEMBL17545844 | 0.75 | KDM4E (0.70) | KDM4EGAAADORA2AMAPTLMNA | |
| SCHEMBL15443102 | 0.75 | KDM4E (0.70) | KDM4EGAAADORA2AL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2669274-B1 | TOPICAL ANTIFUNGAL AGENT | MEIJI SEIKA PHARMA CO LTD (JP) | 2015-11-18 | — | — | EP | claimed |