Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | VDR | P11473 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CD4 | P01730 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25318427 | 0.87 | KEAP1 (0.44) | ALDH1A1HPGDKDM4EKEAP1NFE2L2 | |
| SCHEMBL17258357 | 0.81 | ALDH1A1 (0.43) | ALDH1A1HPGDKDM4EMEN1KMT2A | |
| SCHEMBL16050463 | 0.80 | KEAP1 (0.40) | ALDH1A1HPGDKDM4EKEAP1NFE2L2 | |
| SCHEMBL16050461 | 0.78 | KEAP1 (0.38) | ALDH1A1HPGDKDM4EKEAP1NFE2L2 | |
| SCHEMBL3645222 | 0.78 | KEAP1 (0.40) | ALDH1A1HPGDKDM4EKEAP1NFE2L2 | |
| SCHEMBL16050543 | 0.76 | PSMD10 (0.39) | ALDH1A1HPGDKDM4EKEAP1NFE2L2 | |
| SCHEMBL30400479 | 0.75 | KDM4E (0.37) | ALDH1A1KDM4ELMNA | |
| SCHEMBL17768577 | 0.75 | KDM4E (0.37) | ALDH1A1KDM4ELMNA | |
| SCHEMBL15445196 | 0.75 | GAA (0.42) | ALDH1A1HPGDKDM4ESTAT3GAA | |
| SCHEMBL15259719 | 0.74 | HRH4 (0.47) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9469656-B2 | HDAC inhibitors as anti-cancer agents | THE UNIVERSITY OF TOLEDO (US) | 2016-10-18 | — | — | US | disclosed |
| US-20150329560-A1 | HDAC Inhibitors as Anti-Cancer Agents | THE UNIVERSITY OF TOLEDO (US) | 2015-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150329560-A1 | HDAC Inhibitors as Anti-Cancer Agents | HDAC1, HDAC4, HDAC5 | ALDH1A1 1221/4885HPGD 1311/4885KDM4E 188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.