Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | VDR | P11473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | CD4 | P01730 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25318427 | 0.87 | KEAP1 (0.44) | KEAP1NFE2L2ALDH1A1HPGDKDM4E | |
| SCHEMBL17536027 | 0.83 | KDM4E (0.39) | KEAP1NFE2L2ALDH1A1HPGDKDM4E | |
| SCHEMBL17536025 | 0.83 | KDM4E (0.39) | KEAP1NFE2L2ALDH1A1HPGDKDM4E | |
| SCHEMBL16050463 | 0.81 | KEAP1 (0.40) | KEAP1NFE2L2ALDH1A1HPGDKDM4E | |
| SCHEMBL3645222 | 0.81 | KEAP1 (0.40) | KEAP1NFE2L2ALDH1A1HPGDKDM4E | |
| SCHEMBL17258376 | 0.78 | ALDH1A1 (0.36) | KEAP1NFE2L2ALDH1A1HPGDKDM4E | |
| SCHEMBL16050543 | 0.76 | PSMD10 (0.39) | KEAP1NFE2L2ALDH1A1HPGDKDM4E | |
| SCHEMBL3777059 | 0.74 | SYK (0.50) | ALDH1A1KDM4EKMT2ALMNAPTGS2 | |
| SCHEMBL29995677 | 0.74 | SYK (0.50) | ALDH1A1KDM4EKMT2ALMNAPTGS2 | |
| SCHEMBL30041498 | 0.74 | KDM4E (0.50) | KEAP1NFE2L2ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11945838-B2 | Method for synthesis of protein amphiphiles | INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH (IN) | 2024-04-02 | — | — | US | disclosed |
| US-20200199175-A1 | METHOD FOR SYNTHESIS OF PROTEIN AMPHIPHILES | INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH | 2020-06-25 | — | — | US | disclosed |
| EP-2970307-B1 | PYRAZOLO COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-03-11 | — | — | EP | disclosed |
| US-10035801-B2 | Pyrazolo compounds and uses thereof | GENENTECH, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| US-20160060267-A1 | PYRAZOLO COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-03-03 | — | — | US | disclosed |
| US-20160060267-A1 | PYRAZOLO COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-03-03 | — | — | US | disclosed |
| EP-2970307-A1 | PYRAZOLO COMPOUNDS AND USES THEREOF | Genentech, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2015135094-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2015-09-17 | — | — | WO | disclosed |
| WO-2015135094-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2015-09-17 | — | — | WO | disclosed |
| WO-2014139326-A1 | PYRAZOLO COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014139326-A1 | PYRAZOLO COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200199175-A1 | METHOD FOR SYNTHESIS OF PROTEIN AMPHIPHILES | PTMS, VAC14, PDIA6 | KEAP1 1579/4885NFE2L2 4416/4885ALDH1A1 4784/4885 |
| US-10035801-B2 | Pyrazolo compounds and uses thereof | KDM5A, KDM5C, KDM5B | KEAP1 447/4885NFE2L2 2339/4885ALDH1A1 1424/4885 |
| US-20160060267-A1 | PYRAZOLO COMPOUNDS AND USES THEREOF | KDM5A, KDM5C, KDM5B | KEAP1 447/4885NFE2L2 2339/4885ALDH1A1 1424/4885 |
| US-11945838-B2 | Method for synthesis of protein amphiphiles | PTMS, VAC14, PDIA6 | KEAP1 1579/4885NFE2L2 4416/4885ALDH1A1 4784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.