SCHEMBL1726231

SCHEMBL1726231

Cc1cc(C)c([SiH](c2c(C)cc(C)cc2C)c2c(C)cc(C)cc2C)c(C)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 8/20 0.43
ALDH1A1 P00352 4/20 0.36
KDM4E B2RXH2 2/20 0.36
LMNA P02545 1/20 0.36
GAA P10253 1/20 0.36
MAPT P10636 1/20 0.36
TSHR P16473 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2A6 P11509 1/20 0.35
TP53 P04637 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
MMP1 P03956 1/20 0.32
MMP2 P08253 1/20 0.32
MMP9 P14780 1/20 0.32
MMP8 P22894 1/20 0.32
MMP13 P45452 1/20 0.32
GRIN2D O15399 1/20 0.32
GRIN3B O60391 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8384863 0.80 RAPGEF4 (0.50) RAPGEF4ALDH1A1KDM4ELMNAGAA
SCHEMBL1635401 0.78 RAPGEF4 (0.41) RAPGEF4ALDH1A1KDM4ELMNAGAA
SCHEMBL29776866 0.78 RAPGEF4 (0.41) RAPGEF4ALDH1A1KDM4ELMNAGAA
SCHEMBL8380464 0.78 RAPGEF4 (0.41) RAPGEF4ALDH1A1KDM4ELMNAGAA
SCHEMBL23011314 0.77 CYP1A2 (0.40) RAPGEF4LMNAMAPTTSHRCYP1A2
SCHEMBL3482381 0.75 RAPGEF4 (0.39) RAPGEF4ALDH1A1KDM4ELMNAGAA
SCHEMBL3482176 0.75 RAPGEF4 (0.39) RAPGEF4ALDH1A1KDM4ELMNAGAA
SCHEMBL26265074 0.75 RAPGEF4 (0.39) RAPGEF4ALDH1A1KDM4ELMNAGAA
SCHEMBL23414017 0.75 RAPGEF4 (0.39) RAPGEF4ALDH1A1KDM4ELMNAGAA
SCHEMBL8382049 0.75 RAPGEF4 (0.39) RAPGEF4ALDH1A1KDM4ELMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2403842-B1 CHIRAL DISULFONIMIDES STUDIENGESELLSCHAFT KOHLE MBH (DE) 2016-06-29 EP claimed
US-9079869-B2 Chiral disulfonimides STUDIENGESELLSCHAFT KOHLE MBH (DE) 2015-07-14 US claimed
EP-2403842-A1 CHIRAL DISULFONIMIDES Studiengesellschaft Kohle MbH (DE) 2012-01-11 EP claimed
US-20110313150-A1 CHIRAL DISULFONIMIDES STUDIENGESELLSCHAFT KOHLE MBH (DE) 2011-12-22 US claimed
WO-2010099786-A1 CHIRAL DISULFONIMIDES STUDIENGESELLSCHAFT KOHLE MBH (DE) 2010-09-10 WO claimed
EP-1034196-B1 CATALYST AND METHODS FOR POLYMERIZING CYCLOOLEFINS PROMERUS LLC (US) 2005-01-12 EP claimed
US-12043618-B2 Organic compound, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2024-07-23 US disclosed
US-20230406870-A1 PROCESS FOR PREPARING DIMERIC PHOSPHAZENE DERIVED BRØNSTED ACIDS STUDIENGESELLSCHAFT KOHLE GGMBH (DE) 2023-12-21 US disclosed
EP-4200308-A1 PROCESS FOR PREPARING DIMERIC PHOSPHAZENE DERIVED BRØNSTED ACIDS Studiengesellschaft Kohle gGmbH (DE) 2023-06-28 EP disclosed
US-20230150988-A1 Organic Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2023-05-18 US disclosed
US-11555030-B2 Organic compound, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2023-01-17 US disclosed
WO-2022073803-A1 PROCESS FOR PREPARING DIMERIC PHOSPHAZENE DERIVED BRØNSTED ACIDS STUDIENGESELLSCHAFT KOHLE MBH (DE) 2022-04-14 WO disclosed
US-11084834-B2 Chiral phosphoramidimidates and derivatives thereof STUDIENGESELLSCHAFT KOHLE MBH (DE) 2021-08-10 US disclosed
US-6395846-B1 COORDINATION CATALYST COMPRISING CLAY, ORGANOSILANE COMPOUND, WATER, AND TRANSITION METAL COMPLEX; QUALITY IDEMITSU PETROCHEMICAL CO., LTD. (JP) 2002-05-28 US disclosed
US-6335405-B1 Catalysts for olefin polymer production and process for producing olefin polymer IDEMITSU PETROCHEMICAL CO., LTD. (JP) 2002-01-01 US disclosed
US-6255244-B1 OBTAINED BY CONTACTING A TRANSITION METAL COMPOUND, AN OXYGEN-CONTAINING COMPOUND TO FORM AN IONIC COMPLEX, AND AN ADSORBING SUBSTANCE DURING OR AFTER THE CONTACTING TREATMENT, THEN FOLLOWED BY REMOVING THE ADSORBING SUBSTANCE. IDEMITSU PETROCHEMICAL CO., LTD. (JP) 2001-07-03 US disclosed
EP-1054021-A1 CATALYST FOR OLEFIN POLYMERIZATION AND PROCESS FOR PRODUCING OLEFIN POLYMER WITH THE CATALYST Idemitsu Petrochemical Co., Ltd. (JP) 2000-11-22 EP disclosed
EP-1041085-A1 Catalyst for the production of ethylene polymer and process for producing ethylene polymer Japan Polyolefins Co., Ltd. (JP) 2000-10-04 EP disclosed
EP-1026176-A1 CATALYST FOR OLEFIN POLYMER PRODUCTION, PROCESS FOR PRODUCING THE SAME, AND PROCESS FOR PRODUCING OLEFIN POLYMER IDEMITSU PETROCHEMICAL CO., LTD. (JP) 2000-08-09 EP disclosed
EP-0985685-A1 CATALYSTS FOR OLEFIN POLYMER PRODUCTION AND PROCESS FOR PRODUCING OLEFIN POLYMER Idemitsu Petrochemical Co., Ltd. (JP) 2000-03-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150988-A1 Organic Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device CYP1A1, CYP1B1, CHRM1 RAPGEF4 3604/4885ALDH1A1 482/4885KDM4E 3940/4885
US-20230406870-A1 PROCESS FOR PREPARING DIMERIC PHOSPHAZENE DERIVED BRØNSTED ACIDS PHOSPHO1, BRPF1, BRD9 RAPGEF4 123/4885ALDH1A1 3679/4885KDM4E 3341/4885
US-12043618-B2 Organic compound, light-emitting element, light-emitting device, electronic device, and lighting device CYP1A1, CYP1B1, CHRM1 RAPGEF4 3604/4885ALDH1A1 482/4885KDM4E 3940/4885
US-11084834-B2 Chiral phosphoramidimidates and derivatives thereof PLCB3, PIN1, PLCD1 RAPGEF4 559/4885ALDH1A1 3621/4885KDM4E 4152/4885
US-11555030-B2 Organic compound, light-emitting element, light-emitting device, electronic device, and lighting device CYP1A1, CYP1B1, CHRM1 RAPGEF4 3604/4885ALDH1A1 482/4885KDM4E 3940/4885
US-20110313150-A1 CHIRAL DISULFONIMIDES STS, SUDS3, SF1 RAPGEF4 3908/4885ALDH1A1 86/4885KDM4E 2415/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.