Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 2/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19226484 | 0.85 | PGR (0.43) | SIGMAR1MCHR1HRH4PGRSMN1; SMN2 | |
| SCHEMBL5663838 | 0.84 | SIGMAR1 (0.39) | SIGMAR1MCHR1HRH4PGRNCF1 | |
| SCHEMBL5663844 | 0.84 | SIGMAR1 (0.39) | SIGMAR1MCHR1HRH4PGRNCF1 | |
| SCHEMBL13939978 | 0.81 | SIGMAR1 (0.41) | SIGMAR1MCHR1PGRNCF1ALDH1A1 | |
| SCHEMBL18376167 | 0.79 | SIGMAR1 (0.40) | SIGMAR1MCHR1PGRNCF1ALDH1A1 | |
| SCHEMBL5661288 | 0.79 | SIGMAR1 (0.40) | SIGMAR1MCHR1PGRNCF1ALDH1A1 | |
| SCHEMBL5661285 | 0.79 | SIGMAR1 (0.40) | SIGMAR1MCHR1HRH4PGRNCF1 | |
| SCHEMBL24027442 | 0.78 | TSHR (0.44) | SIGMAR1MCHR1PGRNCF1ALDH1A1 | |
| SCHEMBL23603446 | 0.78 | SIGMAR1 (0.40) | SIGMAR1MCHR1HRH4PGRNCF1 | |
| SCHEMBL17263240 | 0.77 | HRH3 (0.35) | PGRTSHRSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9187441-B2 | p53-Mdm2 antagonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-11-17 | — | — | US | disclosed |