Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727411 | 0.89 | DRD4 (0.47) | RETEGLN1CHRM4DRD4DRD3 | |
| SCHEMBL1729132 | 0.85 | DRD4 (0.52) | EGLN1DRD4DRD3HTR1AHTR2A | |
| SCHEMBL12228947 | 0.84 | RET (0.46) | CD274RETEGLN1CHRM4MKNK1 | |
| SCHEMBL1711102 | 0.83 | CHRM4 (0.59) | EGLN1CHRM4 | |
| SCHEMBL1729537 | 0.83 | DRD4 (0.55) | CD274EGLN1DRD4 | |
| SCHEMBL1728645 | 0.81 | CNR1 (0.50) | CD274EGLN2DRD4DRD3HRH3 | |
| SCHEMBL1727526 | 0.80 | HRH2 (0.47) | RETCHRM4DRD4DRD3HRH2 | |
| SCHEMBL1729393 | 0.79 | CNR2 (0.56) | EGLN1DRD4DRD3HTR1AHTR2A | |
| SCHEMBL1729278 | 0.78 | HTR1A (0.41) | RETEGLN1DRD4DRD3HRH1 | |
| SCHEMBL1729085 | 0.78 | RET (0.41) | RETEGLN1DRD4EP300DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633735-B1 | DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI SA (FR) | 2011-11-30 | — | — | EP | claimed |