Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727700 | 0.89 | KMT2A (0.50) | MEN1KMT2AALDH1A1TSHRHTT | |
| SCHEMBL1728248 | 0.88 | ADORA3 (0.54) | MEN1KMT2AALDH1A1L3MBTL1KCNK3 | |
| SCHEMBL1727750 | 0.88 | KMT2A (0.47) | MEN1KMT2AALDH1A1TSHRHTT | |
| SCHEMBL1726839 | 0.86 | RAB9A (0.55) | MEN1KMT2AALDH1A1RXFP1KCNK3 | |
| SCHEMBL1727843 | 0.85 | PHGDH (0.42) | MEN1KMT2AKCNK3KCNK9MAPK14 | |
| SCHEMBL1727755 | 0.83 | NAMPT (0.53) | MEN1KMT2AALDH1A1HTTL3MBTL1 | |
| SCHEMBL1727677 | 0.82 | NAMPT (0.55) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL1728014 | 0.81 | NPC1 (0.45) | MEN1KMT2AHTTL3MBTL1POLB | |
| SCHEMBL1727825 | 0.80 | RAB9A (0.52) | MEN1KMT2AALDH1A1KCNK9MAPT | |
| SCHEMBL1727761 | 0.79 | KMT2A (0.41) | MEN1KMT2AALDH1A1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403499-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | Stemsynergy Therapeutics, Inc (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101964-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS, INC (US) | 2010-09-10 | — | — | WO | disclosed |