Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727677 | 0.89 | NAMPT (0.55) | NAMPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1727825 | 0.85 | RAB9A (0.52) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL1727700 | 0.84 | KMT2A (0.50) | KMT2AMEN1SMN1; SMN2ALDH1A1PKM | |
| SCHEMBL1728014 | 0.83 | NPC1 (0.45) | NAMPTKMT2AMEN1SMN1; SMN2USP2 | |
| SCHEMBL1727750 | 0.83 | KMT2A (0.47) | KMT2AMEN1ALDH1A1L3MBTL1POLB | |
| SCHEMBL1728248 | 0.83 | ADORA3 (0.54) | KMT2AMEN1SMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL1727751 | 0.83 | PARP1 (0.43) | KMT2AMEN1ALDH1A1L3MBTL1POLB | |
| SCHEMBL1728035 | 0.82 | RAB9A (0.52) | KMT2AMEN1PKMLMNARAB9A | |
| SCHEMBL1727761 | 0.81 | KMT2A (0.41) | NAMPTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1726839 | 0.81 | RAB9A (0.55) | KMT2AMEN1SMN1; SMN2ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403499-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | Stemsynergy Therapeutics, Inc (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101964-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS, INC (US) | 2010-09-10 | — | — | WO | disclosed |