Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727761 | 0.89 | KMT2A (0.41) | MEN1KMT2ANAMPTGAAPOLB | |
| SCHEMBL1728187 | 0.87 | ALDH1A1 (0.53) | NPC1MEN1KMT2ARAB9ATP53 | |
| SCHEMBL1728035 | 0.86 | RAB9A (0.52) | NPC1MEN1KMT2ARAB9ALMNA | |
| SCHEMBL1727700 | 0.83 | KMT2A (0.50) | NPC1MEN1KMT2ARAB9ATP53 | |
| SCHEMBL1727755 | 0.83 | NAMPT (0.53) | MEN1KMT2ARAB9ANAMPTPOLB | |
| SCHEMBL1727814 | 0.81 | AKR1C3 (0.46) | MEN1KMT2AGAACA2 | |
| SCHEMBL1727751 | 0.81 | PARP1 (0.43) | MEN1KMT2APOLBL3MBTL1HTT | |
| SCHEMBL1727750 | 0.81 | KMT2A (0.47) | NPC1MEN1KMT2ARAB9ATP53 | |
| SCHEMBL1727825 | 0.81 | RAB9A (0.52) | NPC1MEN1KMT2ARAB9ATP53 | |
| SCHEMBL1728248 | 0.81 | ADORA3 (0.54) | NPC1MEN1KMT2ARAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403499-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | Stemsynergy Therapeutics, Inc (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101964-A2 | METHODS AND COMPOSITIONS USEFUL IN TREATING CANCER AND REDUCING WNT MEDIATED EFFECTS IN A CELL | STEMSYNERGY THERAPEUTICS, INC (US) | 2010-09-10 | — | — | WO | disclosed |