SCHEMBL17279781

SCHEMBL17279781

Cc1cccc(NC(=O)c2c[nH]c(C(=O)Nc3cccc(C)c3)n2)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.56
MEN1 O00255 5/20 0.56
KMT2A Q03164 5/20 0.56
ALDH1A1 P00352 3/20 0.56
LMNA P02545 2/20 0.56
RXFP1 Q9HBX9 1/20 0.54
MAPT P10636 2/20 0.53
KDM4E B2RXH2 1/20 0.53
NPC1 O15118 2/20 0.51
TP53 P04637 2/20 0.51
RAB9A P51151 2/20 0.51
KCNK3 O14649 2/20 0.50
KCNK9 Q9NPC2 2/20 0.50
SCN2A Q99250 1/20 0.50
SCN10A Q9Y5Y9 1/20 0.50
KCNH2 Q12809 1/20 0.50
CD38 P28907 1/20 0.50
HSD17B10 Q99714 1/20 0.50
GAA P10253 1/20 0.49
FLT3 P36888 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28063183 0.82 POLB (0.59) SMN1; SMN2MEN1KMT2AALDH1A1KDM4E
SCHEMBL259295 0.76 SMN1; SMN2 (0.60) SMN1; SMN2MEN1KMT2AALDH1A1LMNA
SCHEMBL18965783 0.75 FLT3 (0.54) SMN1; SMN2MEN1KMT2AALDH1A1LMNA
SCHEMBL30677473 0.74 MEN1 (0.58) SMN1; SMN2MEN1KMT2AALDH1A1LMNA
SCHEMBL259238 0.74 KDR (0.72) SMN1; SMN2MEN1KMT2AALDH1A1LMNA
SCHEMBL30643208 0.74 KDR (0.72) SMN1; SMN2MEN1KMT2AALDH1A1LMNA
SCHEMBL29723905 0.74 KDR (0.72) SMN1; SMN2MEN1KMT2AALDH1A1LMNA
SCHEMBL23413329 0.73 GAA (0.60) SMN1; SMN2MEN1KMT2AALDH1A1LMNA
SCHEMBL3104769 0.73 SCN2A (0.57) SMN1; SMN2MEN1KMT2AALDH1A1LMNA
SCHEMBL30097611 0.73 GAA (0.60) SMN1; SMN2MEN1KMT2AALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180203175-A1 TRIAZOLE COMPOUND Konica Minolta, Inc. (JP) 2018-07-19 US disclosed
US-20180203175-A1 TRIAZOLE COMPOUND Konica Minolta, Inc. (JP) 2018-07-19 US disclosed
US-10012777-B2 Resin composition Konica Minolta, Inc. (JP) 2018-07-03 US disclosed
US-10012777-B2 Resin composition Konica Minolta, Inc. (JP) 2018-07-03 US disclosed
WO-2017099041-A1 POLYIMIDE FILM, FLEXIBLE PRINTED BOARD, LED LIGHTING DEVICE ETC. コニカミノルタ株式会社 2017-06-15 WO disclosed
US-20150338563-A1 RESIN COMPOSITION, TRIAZOLE COMPOUND, OPTICAL FILM, POLARIZING PLATE, OPTICAL LENS, CIRCULARLY POLARIZING PLATE AND IMAGE DISPLAY DEVICE KONICA MINOLTA, INC (JP) 2015-11-26 US disclosed
US-20150338563-A1 RESIN COMPOSITION, TRIAZOLE COMPOUND, OPTICAL FILM, POLARIZING PLATE, OPTICAL LENS, CIRCULARLY POLARIZING PLATE AND IMAGE DISPLAY DEVICE KONICA MINOLTA, INC (JP) 2015-11-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150338563-A1 RESIN COMPOSITION, TRIAZOLE COMPOUND, OPTICAL FILM, POLARIZING PLATE, OPTICAL LENS, CIRCULARLY POLARIZING PLATE AND IMAGE DISPLAY DEVICE HRH3, HELZ, NBAS SMN1; SMN2 4639/4885MEN1 2695/4885KMT2A 3422/4885
US-10012777-B2 Resin composition NBAS, WDR5, HRH3 SMN1; SMN2 4379/4885MEN1 3131/4885KMT2A 2680/4885
US-20180203175-A1 TRIAZOLE COMPOUND H1-10, TTI2, H1-2 SMN1; SMN2 4539/4885MEN1 1122/4885KMT2A 1136/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.