SCHEMBL1728022

SCHEMBL1728022

Nc1cncc(N2CCC(C(N)CN(CC=O)C(=O)O)CC2)n1

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 1/20 0.34
PIM2 Q9P1W9 1/20 0.34
DPP4 P27487 2/20 0.33
DPP8 Q6V1X1 2/20 0.33
DPP9 Q86TI2 2/20 0.33
DPP7 Q9UHL4 2/20 0.33
CKS1B P61024 2/20 0.31
SKP1 P63208 2/20 0.31
SKP2 Q13309 2/20 0.31
HRH3 Q9Y5N1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1729204 0.85 KDM4E (0.44) DPP4DPP8DPP9DPP7
SCHEMBL1730303 0.83 LMNA (0.36) DPP4DPP8DPP9DPP7
SCHEMBL1730312 0.81 CRHBP (0.43) HRH3
SCHEMBL1729040 0.81 HCAR2 (0.46) DPP4DPP8DPP9DPP7CKS1B
SCHEMBL1730251 0.80 DPP4 (0.42) DPP4DPP8DPP9DPP7CKS1B
SCHEMBL1730161 0.79 DEGS1 (0.43)
SCHEMBL1727545 0.79 GRIN2D (0.36) PIM2DPP4DPP8DPP9DPP7
SCHEMBL1730188 0.79 AKR1C3 (0.39) DPP4DPP8DPP9DPP7HRH3
SCHEMBL1729774 0.79 LMNA (0.36) DPP4DPP8DPP9DPP7
SCHEMBL1727957 0.78 KDM4E (0.45) DPP4DPP8DPP9DPP7HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1633735-B1 DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS SANOFI SA (FR) 2011-11-30 EP claimed