Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 2/20 | 0.49 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.49 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6039578 | 0.90 | GNAI3 (0.43) | GNAI3GNAO1GNAI1SMN1; SMN2NPSR1 | |
| SCHEMBL13136694 | 0.85 | L3MBTL1 (0.52) | SMN1; SMN2TP53DRD2DRD4KDM4E | |
| SCHEMBL21815092 | 0.85 | GNAI3 (0.46) | GNAI3GNAO1GNAI1SMN1; SMN2TP53 | |
| SCHEMBL861408 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2TP53DRD2DRD4KDM4E | |
| SCHEMBL21985476 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2TP53DRD2DRD4KDM4E | |
| SCHEMBL22878224 | 0.83 | SMN1; SMN2 (0.45) | GNAI3GNAO1GNAI1SMN1; SMN2TP53 | |
| SCHEMBL20761009 | 0.81 | SMN1; SMN2 (0.50) | GNAI3GNAO1GNAI1SMN1; SMN2TP53 | |
| SCHEMBL17281925 | 0.81 | SMN1; SMN2 (0.49) | SMN1; SMN2TP53DRD2DRD4KDM4E | |
| SCHEMBL3251521 | 0.80 | MAPK1 (0.52) | SMN1; SMN2TP53DRD2DRD4KDM4E | |
| SCHEMBL6700 | 0.79 | DRD2 (0.53) | DRD2GAAEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015177326-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-11-26 | — | — | WO | disclosed |