Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RORA | P35398 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | RORB | Q92753 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3476935 | 0.79 | NR1I2 (0.44) | ALDH1A1SMN1; SMN2KMT2AAPOBEC3GNR1I2 | |
| SCHEMBL1093290 | 0.79 | APOBEC3G (0.52) | ALDH1A1SMN1; SMN2KDM4EKMT2AAPOBEC3G | |
| SCHEMBL1094120 | 0.76 | KDM4E (0.49) | ALDH1A1SMN1; SMN2KDM4EKMT2AAPOBEC3G | |
| SCHEMBL3828857 | 0.76 | ALDH1A1 (0.80) | ALDH1A1PKMESR1SMN1; SMN2KDM4E | |
| SCHEMBL812682 | 0.75 | PKM (0.79) | ALDH1A1PKMESR1SMN1; SMN2KMT2A | |
| SCHEMBL20238304 | 0.74 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2KDM4EKMT2AAPOBEC3G | |
| SCHEMBL12482553 | 0.73 | HSD11B1 (0.34) | ALDH1A1 | |
| SCHEMBL28235555 | 0.72 | PKM (0.58) | ALDH1A1PKMESR1KMT2AAPOBEC3G | |
| SCHEMBL14058258 | 0.71 | PKM (0.51) | ALDH1A1PKMESR1KDM4EKMT2A | |
| SCHEMBL1101233 | 0.70 | PKM (0.50) | ALDH1A1PKMESR1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678336-A1 | THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2014-01-01 | — | — | EP | disclosed |
| WO-2012113774-A1 | THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-08-30 | — | — | WO | disclosed |
| EP-2406234-A1 | THIAZOLE SULFONAMIDE AND OXAZOLE SULFONAMIDE KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010104899-A1 | THIAZOLE SULFONAMIDE AND OXAZOLE SULFONAMIDE KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2010-09-16 | — | — | WO | disclosed |