Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 5/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | TTR | P02766 | 3/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28056217 | 0.88 | ALDH1A1 (0.78) | KDM4EHSD17B10ALDH1A1GAAMAPK1 | |
| SCHEMBL15776926 | 0.88 | KDM4E (0.78) | KDM4EHSD17B10ALDH1A1GAAMAPK1 | |
| SCHEMBL23292230 | 0.84 | GAA (0.77) | KDM4EHSD17B10ALDH1A1GAAMAPK1 | |
| SCHEMBL22895657 | 0.84 | KDM4E (0.60) | KDM4EHSD17B10ALDH1A1GAAMAPK1 | |
| SCHEMBL17287387 | 0.81 | KDM4E (0.53) | KDM4EHSD17B10ALDH1A1GAAMAPK1 | |
| SCHEMBL22895541 | 0.81 | LGMN (0.59) | KDM4EHSD17B10ALDH1A1GAAMAPK1 | |
| SCHEMBL12752917 | 0.79 | HSD17B10 (0.57) | KDM4EHSD17B10ALDH1A1GAAMAPK1 | |
| SCHEMBL5827458 | 0.79 | HTR1D (0.55) | MAPK1HTTPOLBLMNANPC1 | |
| SCHEMBL28291873 | 0.78 | KDM4E (0.53) | KDM4EHSD17B10ALDH1A1GAAMAPK1 | |
| SCHEMBL2430511 | 0.78 | KDM4E (0.56) | KDM4EHSD17B10ALDH1A1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11390618-B2 | Inhibitors of cyclin-dependent kinases | KINNATE BIOPHARMA INC. (US) | 2022-07-19 | — | — | US | disclosed |
| US-11358958-B2 | — | — | 2022-06-14 | — | — | US | disclosed |
| US-11358958-B2 | — | — | 2022-06-14 | — | — | US | disclosed |
| US-20210130340-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | KINNATE BIOPHARMA INC. | 2021-05-06 | — | — | US | disclosed |
| US-20210130340-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | KINNATE BIOPHARMA INC. | 2021-05-06 | — | — | US | disclosed |
| EP-3813819-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | Kinnate Biopharma Inc. (US) | 2021-05-05 | — | — | EP | disclosed |
| CN-112638373-A | Cyclin-dependent kinase inhibitors | 金耐特生物制药公司 | 2021-04-09 | — | — | CN | disclosed |
| US-10894788-B2 | Inhibitors of cyclin-dependent kinases | KINNATE BIOPHARMA INC. (US) | 2021-01-19 | — | — | US | disclosed |
| US-10894788-B2 | Inhibitors of cyclin-dependent kinases | KINNATE BIOPHARMA INC. (US) | 2021-01-19 | — | — | US | disclosed |
| US-10233165-B2 | Cyclopropylamine compounds as histone demethylase inhibitors | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2019-03-19 | — | — | US | disclosed |
| EP-3148974-B1 | CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | ST EUROPEO DI ONCOLOGIA S R L (IT) | 2018-09-26 | — | — | EP | disclosed |
| US-20170190680-A1 | CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2017-07-06 | — | — | US | disclosed |
| EP-3148974-A1 | CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | Istituto Europeo di Oncologia S.r.l. (IT) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181380-A1 | CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2015-12-03 | — | — | WO | disclosed |
| EP-2949648-A1 | Cyclopropylamine derivatives as histone demethylase inhibitors | IEO - Istituto Europeo di Oncologia Srl (IT) | 2015-12-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11358958-B2 | — | CDK2, CDK1, CDK6 | KDM4E 1178/4885HSD17B10 2396/4885ALDH1A1 3425/4885 |
| US-20210130340-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | CDK2, CCNK, CDK1 | KDM4E 1278/4885HSD17B10 2436/4885ALDH1A1 3722/4885 |
| US-10894788-B2 | Inhibitors of cyclin-dependent kinases | CDK2, CCNK, CDK1 | KDM4E 1278/4885HSD17B10 2436/4885ALDH1A1 3722/4885 |
| US-10233165-B2 | Cyclopropylamine compounds as histone demethylase inhibitors | KDM1B, PHF2, KDM6B | KDM4E 14/4885HSD17B10 875/4885ALDH1A1 533/4885 |
| US-11390618-B2 | Inhibitors of cyclin-dependent kinases | CDK2, CCNK, CDK1 | KDM4E 1278/4885HSD17B10 2436/4885ALDH1A1 3722/4885 |
| US-20170190680-A1 | CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS | KDM1B, PHF2, KDM6B | KDM4E 14/4885HSD17B10 875/4885ALDH1A1 533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.