Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.55 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.48 |
| ▸ | SCD | O00767 | 2/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL346050 | 0.92 | HRH3 (0.56) | HRH3HTR3APDE10ASCDCHRM4 | |
| SCHEMBL1722961 | 0.87 | PDE10A (0.48) | HRH3PDE10ASCDPDE2ACHRM4 | |
| SCHEMBL1727542 | 0.85 | HRH3 (0.52) | HRH3PDE10APDE2A | |
| SCHEMBL3268726 | 0.84 | HRH3 (0.45) | HRH3HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL1730076 | 0.83 | CHRM4 (0.46) | SCDCHRM4MAOAMAOBDGAT1 | |
| SCHEMBL3268730 | 0.82 | FAAH (0.46) | HRH3HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL1728730 | 0.81 | MAOA (0.55) | PDE10ACHRM4MAOAMAOBCHRM2 | |
| SCHEMBL345345 | 0.81 | HRH3 (0.50) | HRH3PDE10ASCDPDE2ACHRM4 | |
| SCHEMBL1728843 | 0.81 | P2RX7 (0.46) | CHRM4 | |
| SCHEMBL1728851 | 0.81 | HRH3 (0.58) | HRH3HTR3APDE10ADGAT1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633735-B1 | DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI SA (FR) | 2011-11-30 | — | — | EP | claimed |