Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | GPR6 | P46095 | 9/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729857 | 0.88 | GPR6 (0.39) | SIRT2SIRT1SIRT3PDE10ADPP4 | |
| SCHEMBL1729384 | 0.86 | DPP4 (0.44) | SIRT2SIRT1SIRT3PDE10ADPP4 | |
| SCHEMBL1728948 | 0.86 | ENPP1 (0.43) | SIRT2SIRT1SIRT3GPR6AOC3 | |
| SCHEMBL1728840 | 0.80 | HTR1A (0.39) | ACHERBP4TTR | |
| SCHEMBL239086 | 0.78 | PDE10A (0.47) | SIRT2SIRT1SIRT3PDE10ADPP4 | |
| SCHEMBL1727950 | 0.78 | SIRT2 (0.50) | SIRT2SIRT1SIRT3PDE10AGPR6 | |
| SCHEMBL1727905 | 0.77 | KMT2A (0.39) | SIRT2SIRT1SIRT3AOC3RBP4 | |
| SCHEMBL1727605 | 0.77 | DGAT1 (0.44) | AOC3 | |
| SCHEMBL238082 | 0.76 | SIRT2 (0.49) | SIRT2SIRT1SIRT3GPR6AOC3 | |
| SCHEMBL1729231 | 0.76 | KDM4E (0.40) | AOC3RBP4TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633735-B1 | DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI SA (FR) | 2011-11-30 | — | — | EP | claimed |