Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | SORD | Q00796 | 2/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727927 | 0.87 | HRH4 (0.44) | DPP4DPP7HRH4HTR2CACHE | |
| SCHEMBL1728989 | 0.86 | SIRT2 (0.40) | DPP4DPP7ACHESIRT2SIRT1 | |
| SCHEMBL1728948 | 0.84 | ENPP1 (0.43) | ACHEMALT1SIRT2SIRT1SIRT3 | |
| SCHEMBL1729120 | 0.83 | F10 (0.44) | HTR2CSIRT2SIRT1SIRT3DRD2 | |
| SCHEMBL1729231 | 0.83 | KDM4E (0.40) | MALT1DRD2 | |
| SCHEMBL1727905 | 0.82 | KMT2A (0.39) | MALT1SIRT2SIRT1SIRT3 | |
| SCHEMBL1730249 | 0.80 | HTR3A (0.42) | — | |
| SCHEMBL1727953 | 0.79 | PDE10A (0.45) | DPP4DPP7HTR2CPDE10A | |
| SCHEMBL1729269 | 0.79 | AKR1C3 (0.45) | HTR2CDRD2DRD3 | |
| SCHEMBL1728042 | 0.79 | RXRA (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633735-B1 | DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI SA (FR) | 2011-11-30 | — | — | EP | claimed |