Sugi Predict

Sugi Predict / Compounds / SCHEMBL17291310

SCHEMBL17291310

SCHEMBL17291310

CC(=O)NC(c1ccc(F)c(F)c1)S(=O)(=O)c1ccc(C)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.48
▸ KMT2A Q03164 2/20 0.48
▸ ALDH1A1 P00352 5/20 0.43
▸ LMNA P02545 4/20 0.43
▸ TSHR P16473 1/20 0.43
▸ PKM P14618 2/20 0.41
▸ TP53 P04637 1/20 0.39
▸ CNR1 P21554 1/20 0.39
▸ CA12 O43570 1/20 0.38
▸ CA1 P00915 1/20 0.38
▸ CA2 P00918 1/20 0.38
▸ CA9 Q16790 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ PTGS2 P35354 2/20 0.38
▸ IDO1 P14902 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ RXFP1 Q9HBX9 1/20 0.37
▸ PTGS1 P23219 1/20 0.37
▸ POLB P06746 1/20 0.36
▸ MAPT P10636 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17291386 0.91 ALDH1A1 (0.42) MEN1KMT2AALDH1A1LMNATSHR
SCHEMBL19732921 0.88 MEN1 (0.44) MEN1KMT2AALDH1A1LMNATSHR
SCHEMBL17291408 0.86 PKM (0.50) MEN1KMT2AALDH1A1LMNATSHR
SCHEMBL1639850 0.85 TP53 (0.51) MEN1KMT2AALDH1A1LMNAPKM
SCHEMBL17291348 0.82 LMNA (0.50) MEN1KMT2AALDH1A1LMNAPKM
SCHEMBL5741463 0.80 KMT2A (0.40) MEN1KMT2AALDH1A1LMNATSHR
SCHEMBL9961396 0.79 LMNA (0.49) KMT2AALDH1A1LMNATSHRPKM
SCHEMBL2763497 0.75 TP53 (0.49) MEN1KMT2AALDH1A1LMNATP53
SCHEMBL19732939 0.73 TP53 (0.47) MEN1KMT2AALDH1A1LMNATP53
SCHEMBL19732946 0.73 LMNA (0.51) ALDH1A1LMNAPKMCA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2935271-B1 NOVEL SUBSTITUTED IMIDAZOLES AS CASEIN KINASE 1 / INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2017-10-25 — — EP disclosed
EP-2935271-B1 NOVEL SUBSTITUTED IMIDAZOLES AS CASEIN KINASE 1 / INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2017-10-25 — — EP disclosed
US-9556179-B2 Substituted imidazoles as casein kinase 1 D/E inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2017-01-31 — — US disclosed
US-9556179-B2 Substituted imidazoles as casein kinase 1 D/E inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2017-01-31 — — US disclosed
US-9556179-B2 Substituted imidazoles as casein kinase 1 D/E inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2017-01-31 — — US disclosed
US-20150344481-A1 NOVEL SUBSTITUTED IMIDAZOLES AS CASEIN KINASE 1 D/E INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2015-12-03 — — US disclosed
US-20150344481-A1 NOVEL SUBSTITUTED IMIDAZOLES AS CASEIN KINASE 1 D/E INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2015-12-03 — — US disclosed
US-20150344481-A1 NOVEL SUBSTITUTED IMIDAZOLES AS CASEIN KINASE 1 D/E INHIBITORS BRISTOL-MYERS SQUIBB COMPANY 2015-12-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150344481-A1 NOVEL SUBSTITUTED IMIDAZOLES AS CASEIN KINASE 1 D/E INHIBITORS CSNK1E, CSNK1A1, CSNK1G1 MEN1 2867/4885KMT2A 1521/4885ALDH1A1 2235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.