Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | EDNRB | P24530 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17294177 | 0.89 | HDAC1 (0.46) | SMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL17294147 | 0.85 | MMP2 (0.49) | PTGS2 | |
| SCHEMBL10576223 | 0.68 | ALDH1A1 (0.46) | SMN1; SMN2HTTKMT2AALDH1A1HSD17B10 | |
| SCHEMBL4560949 | 0.68 | ALDH1A1 (0.46) | SMN1; SMN2HTTKMT2AALDH1A1HSD17B10 | |
| SCHEMBL2893747 | 0.68 | ALDH1A1 (0.46) | SMN1; SMN2HTTKMT2AALDH1A1HSD17B10 | |
| SCHEMBL17294164 | 0.68 | MMP2 (0.43) | ALDH1A1POLBHSD17B10 | |
| SCHEMBL10073203 | 0.67 | PTGS2 (0.64) | PTGS2PDE5APTGS1KMT2AALDH1A1 | |
| SCHEMBL7234080 | 0.65 | HDAC1 (0.49) | SMN1; SMN2KMT2AALDH1A1MEN1HSD17B10 | |
| SCHEMBL7113133 | 0.65 | KMT2A (0.59) | SMN1; SMN2KMT2AALDH1A1MEN1HSD17B10 | |
| SCHEMBL5749606 | 0.65 | TAAR1 (0.54) | SMN1; SMN2KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148983-A1 | N-HYDROXYLAMINO-BARBITURIC ACID DERIVATIVES AS NITROXYL DONORS | The Johns Hopkins University (US) | 2017-04-05 | — | — | EP | claimed |
| WO-2015183838-A1 | N-HYDROXYLAMINO-BARBITURIC ACID DERIVATIVES AS NITROXYL DONORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2015-12-03 | — | — | WO | claimed |