Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 6/20 | 0.50 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7252808 | 0.75 | PPARG (0.82) | PPARGPPARAKMT2AMEN1CLCN2 | |
| SCHEMBL26670900 | 0.73 | PLK1 (0.62) | PLK1PLK3KMT2AMEN1GFER | |
| SCHEMBL19554157 | 0.73 | PPARG (0.56) | PPARGPPARAKMT2AMEN1GFER | |
| SCHEMBL1105964 | 0.73 | HCAR2 (0.47) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL6891543 | 0.70 | KMT2A (0.55) | PLK1PLK3PPARGPPARAKMT2A | |
| SCHEMBL10895501 | 0.68 | KCNMA1 (0.69) | KMT2AMEN1GFERRAB9ALMNA | |
| SCHEMBL31670343 | 0.68 | KCNMA1 (0.69) | KMT2AMEN1GFERRAB9ALMNA | |
| SCHEMBL12172774 | 0.68 | RAB9A (0.61) | PPARGPPARAKMT2AMEN1ALDH1A1 | |
| SCHEMBL22839400 | 0.68 | KMT2A (0.65) | KMT2AMEN1ALDH1A1RAB9ALMNA | |
| SCHEMBL1307704 | 0.68 | GRIK1 (0.65) | KMT2AMEN1ALDH1A1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148975-A1 | NOVEL COMPOUNDS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015180612-A1 | NOVEL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2015-12-03 | — | — | WO | disclosed |