Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3455457 | 0.72 | MAPT (0.60) | ALDH1A1USP2LMNATSHRMEN1 | |
| SCHEMBL1000208 | 0.72 | RAB9A (0.66) | ALDH1A1USP2RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9273051 | 0.71 | MEN1 (0.52) | ALDH1A1TSHRMEN1KMT2ARAB9A | |
| SCHEMBL9273047 | 0.71 | MEN1 (0.52) | ALDH1A1TSHRMEN1KMT2ARAB9A | |
| SCHEMBL13900631 | 0.70 | ALDH1A1 (0.52) | HTTALDH1A1USP2LMNATSHR | |
| SCHEMBL14761125 | 0.69 | ALDH1A1 (0.51) | HTTALDH1A1USP2LMNATSHR | |
| SCHEMBL28268613 | 0.67 | RAB9A (0.75) | HTTALDH1A1LMNATSHRMEN1 | |
| SCHEMBL29354384 | 0.66 | RAB9A (1.00) | ALDH1A1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL16654340 | 0.65 | ALDH1A1 (0.54) | HTTALDH1A1LMNATSHRMEN1 | |
| SCHEMBL3285958 | 0.65 | ALDH1A1 (0.53) | HTTALDH1A1USP2LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240390467-A1 | PROHEMOSTATIC PROTEINS FOR THE TREATMENT OF BLEEDING | ACADEMISCH ZIEKENHUIS LEIDEN (NL) | 2024-11-28 | — | — | US | disclosed |
| US-12083170-B2 | Prohemostatic proteins for the treatment of bleeding | ACADEMISCH ZIEKENHUIS LEIDEN (NL) | 2024-09-10 | — | — | US | disclosed |
| US-20220288172-A1 | PROHEMOSTATIC PROTEINS FOR THE TREATMENT OF BLEEDING | ACADEMISCH ZIEKENHUIS LEIDEN (US) | 2022-09-15 | — | — | US | disclosed |
| US-11357836-B2 | Prohemostatic proteins for the treatment of bleeding | ACADEMISCH ZIEKENHUIS LEIDEN (NL) | 2022-06-14 | — | — | US | disclosed |
| US-11304995-B2 | Prohemostatic proteins for the treatment of bleeding | ACADEMISCH ZIEKENHUIS LEIDEN (NL) | 2022-04-19 | — | — | US | disclosed |
| EP-3744840-A1 | PROHEMOSTATIC PROTEINS FOR THE TREATMENT OF BLEEDING | Academisch Ziekenhuis Leiden (NL) | 2020-12-02 | — | — | EP | disclosed |
| EP-3149163-B1 | PROHEMOSTATIC PROTEINS FOR THE TREATMENT OF BLEEDING | ACADEMISCH ZIEKENHUIS LEIDEN (NL) | 2020-06-03 | — | — | EP | disclosed |
| US-20200138917-A1 | PROHEMOSTATIC PROTEINS FOR THE TREATMENT OF BLEEDING | ACADEMISCH ZIEKENHUIS LEIDEN (NL) | 2020-05-07 | — | — | US | disclosed |
| US-20200138916-A1 | PROHEMOSTATIC PROTEINS FOR THE TREATMENT OF BLEEDING | ACADEMISCH ZIEKENHUIS LEIDEN (NL) | 2020-05-07 | — | — | US | disclosed |
| US-10537618-B2 | Prohemostatic proteins for the treatment of bleeding | ACADEMISCH ZIEKENHUIS LEIDEN (NL) | 2020-01-21 | — | — | US | disclosed |
| US-20170157223-A1 | PROHEMOSTATIC PROTEINS FOR THE TREATMENT OF BLEEDING | ACADEMISCH ZIEKENHUIS LEIDEN | 2017-06-08 | — | — | US | disclosed |
| EP-3149163-A1 | PROHEMOSTATIC PROTEINS FOR THE TREATMENT OF BLEEDING | Academisch Ziekenhuis Leiden (NL) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015183085-A1 | PROHEMOSTATIC PROTEINS FOR THE TREATMENT OF BLEEDING | ACADEMISCH ZIEKENHUIS LEIDEN (NL) | 2015-12-03 | — | — | WO | disclosed |