Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17295401 | 1.00 | ALDH1A1 (0.49) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL17295633 | 0.81 | FAAH (0.53) | ALDH1A1MAPTKMT2ACA9POLB | |
| SCHEMBL17295634 | 0.81 | FAAH (0.53) | ALDH1A1MAPTKMT2ACA9POLB | |
| SCHEMBL17295605 | 0.80 | FAAH (0.55) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL17295607 | 0.80 | FAAH (0.55) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL17295299 | 0.78 | ALDH1A1 (0.50) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL17295297 | 0.78 | ALDH1A1 (0.50) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL17295407 | 0.77 | CA9 (0.52) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL17295404 | 0.77 | CA9 (0.52) | ALDH1A1MAPTNPSR1MEN1KMT2A | |
| SCHEMBL19096572 | 0.77 | ALDH1A1 (0.48) | ALDH1A1MAPTNPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148990-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181337-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2015-12-03 | — | — | WO | disclosed |