Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.46 |
| ▸ | CLK1 | P49759 | 3/20 | 0.46 |
| ▸ | CLK3 | P49761 | 3/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.46 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.46 |
| ▸ | DYRK4 | Q9NR20 | 2/20 | 0.46 |
| ▸ | CLK2 | P49760 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.45 |
| ▸ | ESRRA | P11474 | 3/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17295633 | 1.00 | FAAH (0.53) | FAAHDYRK3CLK1CLK3DYRK1A | |
| SCHEMBL17295536 | 0.92 | FAAH (0.52) | FAAHDYRK3CLK1CLK3DYRK1A | |
| SCHEMBL17295534 | 0.92 | FAAH (0.52) | FAAHDYRK3CLK1CLK3DYRK1A | |
| SCHEMBL17295402 | 0.81 | ALDH1A1 (0.49) | FAAHCLK1DYRK1ACLK4DYRK1B | |
| SCHEMBL17295401 | 0.81 | ALDH1A1 (0.49) | FAAHCLK1DYRK1ACLK4DYRK1B | |
| SCHEMBL19096243 | 0.79 | FAAH (0.56) | FAAHDYRK1ADYRK2DYRK1BS1PR1 | |
| SCHEMBL17295567 | 0.78 | FAAH (0.54) | FAAHDYRK3CLK1CLK3DYRK1A | |
| SCHEMBL17295564 | 0.78 | FAAH (0.54) | FAAHDYRK3CLK1CLK3DYRK1A | |
| SCHEMBL17295605 | 0.78 | FAAH (0.55) | FAAHS1PR1S1PR3ALDH1A1POLB | |
| SCHEMBL17295607 | 0.78 | FAAH (0.55) | FAAHS1PR1S1PR3ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148990-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181337-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2015-12-03 | — | — | WO | disclosed |