Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | MGAM | O43451 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SI | P14410 | 1/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17295605 | 1.00 | FAAH (0.55) | FAAHMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL17295434 | 0.85 | FAAH (0.59) | FAAHMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL17295436 | 0.85 | FAAH (0.59) | FAAHMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL17295259 | 0.80 | FAAH (0.57) | FAAHMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL17295257 | 0.80 | FAAH (0.57) | FAAHMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL17295402 | 0.80 | ALDH1A1 (0.49) | FAAHMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL17295401 | 0.80 | ALDH1A1 (0.49) | FAAHMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL17295536 | 0.79 | FAAH (0.52) | FAAHMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL17295534 | 0.79 | FAAH (0.52) | FAAHMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL17295634 | 0.78 | FAAH (0.53) | FAAHKMT2AMAPTCA9S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148990-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181337-A1 | THIAZOLIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF PSYCHIATRIC OR NEUROLOGICAL DISORDERS AND INFLAMMATION, IN PARTICULAR NEUROINFLAMMATION | Universität Bern (CH) | 2015-12-03 | — | — | WO | disclosed |