Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21632972 | 0.85 | MAPK1 (0.43) | ALDH1A1MEN1KMT2ACYP2C19RAB9A | |
| SCHEMBL21840112 | 0.82 | PDGFRB (0.48) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL19874150 | 0.79 | DPP4 (0.47) | ALDH1A1DPP4TNFMEN1KMT2A | |
| SCHEMBL17111627 | 0.78 | MAPK1 (0.45) | ALDH1A1MEN1KMT2ANPC1CYP2C19 | |
| SCHEMBL3567178 | 0.76 | PIN1 (0.44) | ALDH1A1MEN1KMT2ACYP3A4RAB9A | |
| SCHEMBL21632926 | 0.76 | PDGFRB (0.51) | ALDH1A1MEN1KMT2ACYP2C19PKM | |
| SCHEMBL28668958 | 0.76 | RAB9A (0.60) | ALDH1A1DPP4TNFMEN1KMT2A | |
| SCHEMBL15591654 | 0.76 | DPP4 (0.47) | ALDH1A1DPP4TNFMEN1KMT2A | |
| SCHEMBL11263992 | 0.76 | MAPK1 (0.48) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL17781197 | 0.74 | MAPT (0.44) | ALDH1A1DPP4MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783530-B2 | Factor Xla inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-10-10 | — | — | US | disclosed |
| US-20170197953-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-07-13 | — | — | US | disclosed |
| EP-3148542-A1 | FACTOR XIA INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015183709-A1 | FACTOR XIA INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170197953-A1 | FACTOR XIa INHIBITORS | F11, TFPI, F2 | ALDH1A1 3470/4885DPP4 2362/4885TNF 616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.