Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR3A | P46098 | 4/20 | 0.43 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.40 |
| ▸ | HTR3B | O95264 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239521 | 0.78 | P2RX7 (0.48) | HRH3HTR1AHTR3ASETDB1P2RX7 | |
| SCHEMBL6776065 | 0.77 | HTR3A (0.60) | HTR1AHTR3AHTR3EHTR3BCYP1A2 | |
| SCHEMBL1722973 | 0.76 | HRH3 (0.64) | HRH3HTR1AHTR3AHTR3EHTR3B | |
| SCHEMBL5237714 | 0.74 | HTR1A (0.51) | HRH3HTR1AHTR3AMEN1KMT2A | |
| SCHEMBL9989008 | 0.73 | PDE10A (0.74) | PDE10A | |
| SCHEMBL1728843 | 0.73 | P2RX7 (0.46) | HTR1AP2RX7 | |
| SCHEMBL27649156 | 0.73 | HTR1A (0.46) | HRH3HTR1AHTR3AP2RX7HTT | |
| SCHEMBL1730391 | 0.73 | HTR3E (0.57) | HTR3AHTR3EHTR3BCYP1A2HTR3D | |
| SCHEMBL1729381 | 0.73 | GRIN2D (0.47) | HRH3HTR3AHTR3EHTR3BCYP1A2 | |
| SCHEMBL6769797 | 0.71 | PTPN11 (0.44) | HRH3HTR1AHTR3AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633735-B1 | DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI SA (FR) | 2011-11-30 | — | — | EP | disclosed |