Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | LTA4H | P09960 | 4/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728135 | 0.82 | LTA4H (0.51) | MCHR1KCNH2LTA4HFDPS | |
| SCHEMBL6081348 | 0.82 | LTA4H (0.51) | MCHR1KCNH2LTA4HFDPSSMN1; SMN2 | |
| SCHEMBL1728669 | 0.82 | LTA4H (0.68) | MCHR1KCNH2LTA4HSMN1; SMN2 | |
| SCHEMBL1728748 | 0.81 | MCHR1 (0.66) | MCHR1KCNH2LTA4HMEN1KMT2A | |
| SCHEMBL1728610 | 0.81 | KCNH2 (0.57) | MCHR1KCNH2LTA4H | |
| SCHEMBL1728580 | 0.78 | LTA4H (0.51) | MCHR1KCNH2LTA4HSMN1; SMN2MEN1 | |
| SCHEMBL1728662 | 0.78 | MCHR1 (0.47) | MCHR1KCNH2LTA4HMEN1KMT2A | |
| SCHEMBL1728641 | 0.76 | GNRHR (0.48) | MCHR1KCNH2LTA4H | |
| SCHEMBL1728816 | 0.74 | KDM4E (0.47) | MCHR1KCNH2LTA4HSMN1; SMN2 | |
| SCHEMBL1727501 | 0.73 | LTA4H (0.45) | MCHR1KCNH2LTA4HMCHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |