Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.45 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728610 | 0.86 | KCNH2 (0.57) | KCNH2MCHR1LTA4HTSHR | |
| SCHEMBL1728135 | 0.84 | LTA4H (0.51) | KCNH2MCHR1LTA4HTSHR | |
| SCHEMBL6081348 | 0.84 | LTA4H (0.51) | KCNH2MCHR1LTA4HCYP2C9TSHR | |
| SCHEMBL1728669 | 0.81 | LTA4H (0.68) | KDM4EALDH1A1KCNH2MCHR1LTA4H | |
| SCHEMBL1728748 | 0.81 | MCHR1 (0.66) | KDM4EALDH1A1KCNH2MCHR1LTA4H | |
| SCHEMBL1728663 | 0.78 | LTA4H (0.44) | KCNH2MCHR1LTA4HNPSR1 | |
| SCHEMBL1728580 | 0.77 | LTA4H (0.51) | ALDH1A1KCNH2MCHR1LTA4H | |
| SCHEMBL1729935 | 0.76 | MCHR1 (0.45) | KCNH2MCHR1LTA4H | |
| SCHEMBL1728527 | 0.76 | MCHR1 (0.51) | KCNH2MCHR1LTA4HCYP3A4CYP2D6 | |
| SCHEMBL1728773 | 0.74 | CHRNB2 (0.59) | MCHR1LTA4HCYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551810-B1 | DIARYL-SUBSTITUTED CYCLIC UREA DERIVATIVES HAVING AN MCH-MODULATORY EFFECT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-11-30 | — | — | EP | disclosed |
| US-7141561-B2 | Substituted diaryl heterocycles, process for their preparation and their use as medicaments | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-11-28 | — | — | US | disclosed |