Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | PPID | Q08752 | 1/20 | 0.48 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3282735 | 0.91 | ALDH1A1 (0.51) | ALDH1A1LMNAPLAUMAPK14 | |
| SCHEMBL12281982 | 0.89 | MLYCD (0.46) | ALDH1A1LMNATSHRGAAMAPK14 | |
| SCHEMBL3276617 | 0.88 | MAPK14 (0.62) | ALDH1A1LMNAGAAMAPK14 | |
| SCHEMBL11563398 | 0.83 | PLAU (0.49) | ALDH1A1PLAUPPIDMAPTTSHR | |
| SCHEMBL12994525 | 0.83 | LMNA (0.45) | ALDH1A1LMNAPLAUPPIDMAPT | |
| SCHEMBL16937317 | 0.82 | PLAU (0.46) | ALDH1A1LMNAPLAUPPIDTXNRD1 | |
| SCHEMBL1730789 | 0.81 | HDAC3 (0.52) | ALDH1A1GAA | |
| SCHEMBL29924988 | 0.79 | ALDH1A1 (0.49) | ALDH1A1PPIDMAPTTSHRGAA | |
| Benzyl Benzylcarbamate SCHEMBL1136818 | 0.79 | PLAU (0.70) | ALDH1A1LMNAPLAU | |
| SCHEMBL19716546 | 0.79 | PLAU (0.54) | ALDH1A1PLAUPPIDMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673337-B1 | Arylalkylcarbamate derivatives, preparation method thereof and use of same in therapeutics | SANOFI SA (FR) | 2011-11-23 | — | — | EP | claimed |
| US-7696374-B2 | Arylalklcarbamate derivatives, preparation method thereof and use of same in therapeutics | SANOFI-AVENTIS (FR) | 2010-04-13 | — | — | US | claimed |
| US-20060223805-A1 | Arylalklcarbamate derivatives, preparation method thereof and use of same in therapeutics | SANOFI-AVENTIS (FR) | 2006-10-05 | — | — | US | claimed |
| CN-102348698-B | Inhibitors of beta-secretase | VITAE PHARMACEUTICALS INC | 2015-06-03 | — | — | CN | disclosed |
| US-7696374-B2 | Arylalklcarbamate derivatives, preparation method thereof and use of same in therapeutics | SANOFI-AVENTIS (FR) | 2010-04-13 | — | — | US | disclosed |
| EP-1972616-A1 | Derivatives of arylalkylcarbamates, process for their preparation and therapeutic application thereof | Sanofi-Aventis (FR) | 2008-09-24 | — | — | EP | disclosed |
| US-20060223805-A1 | Arylalklcarbamate derivatives, preparation method thereof and use of same in therapeutics | SANOFI-AVENTIS (FR) | 2006-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223805-A1 | Arylalklcarbamate derivatives, preparation method thereof and use of same in therapeutics | GBA1, NAT1, AADAC | ALDH1A1 32/4885LMNA 1935/4885PLAU 2655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.