Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727743 | 0.92 | SIRT2 (0.50) | SIRT2SIRT1SIRT3CYP1A2CYP2D6 | |
| SCHEMBL1729130 | 0.85 | ENPP1 (0.51) | SIRT2SIRT1SIRT3CHRM4MAOA | |
| SCHEMBL1728813 | 0.84 | SIRT2 (0.51) | SIRT2SIRT1SIRT3CHRM4 | |
| SCHEMBL3266982 | 0.83 | SIRT2 (0.45) | SIRT2SIRT1SIRT3CYP1A2CYP2D6 | |
| SCHEMBL1727950 | 0.81 | SIRT2 (0.50) | SIRT2SIRT1SIRT3CHRM4PDE10A | |
| SCHEMBL1730076 | 0.79 | CHRM4 (0.46) | CHRM4MAOAMAOBCHRM1 | |
| SCHEMBL1728435 | 0.78 | SIRT2 (0.50) | SIRT2SIRT1SIRT3CHRM4MAOA | |
| SCHEMBL1727406 | 0.78 | HCAR2 (0.47) | SIRT2SIRT1SIRT3CHRM4 | |
| SCHEMBL1728774 | 0.78 | HRH3 (0.55) | CYP1A2CYP2D6CHRM4MAOAMAOB | |
| SCHEMBL1729450 | 0.78 | CYP1A2 (0.39) | SIRT2SIRT1SIRT3CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633735-B1 | DERIVATIVES OF PIPERIDINYL- AND PIPERAZINYL-ALKYL CARBAMATES, PREPARATION METHODS THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI SA (FR) | 2011-11-30 | — | — | EP | claimed |