Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.61 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.59 |
| ▸ | HRH1 | P35367 | 5/20 | 0.58 |
| ▸ | HRH2 | P25021 | 4/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1730947 | 0.96 | HRH3 (0.69) | LTA4HHRH3HRH1HRH2USP2 | |
| SCHEMBL1714312 | 0.92 | HRH3 (0.71) | HRH3KCNA5HRH1HRH2 | |
| SCHEMBL1730306 | 0.88 | LTA4H (0.77) | LTA4HHRH3KCNA5HRH1HRH2 | |
| SCHEMBL5623066 | 0.87 | HRH3 (0.79) | HRH3KCNA5HRH1HRH2MEN1 | |
| SCHEMBL1728913 | 0.87 | HRH3 (0.51) | LTA4HHRH3KCNA5HRH1HRH2 | |
| SCHEMBL1730425 | 0.86 | LTA4H (0.55) | LTA4HHRH3KCNA5HRH1HRH2 | |
| SCHEMBL1730790 | 0.86 | KCNA5 (0.58) | LTA4HHRH3KCNA5HRH1HRH2 | |
| SCHEMBL4874490 | 0.85 | HRH3 (0.82) | LTA4HHRH3KCNA5HRH1HRH2 | |
| SCHEMBL227297 | 0.84 | HRH3 (0.85) | LTA4HHRH3HRH1HRH2 | |
| SCHEMBL3976172 | 0.84 | HRH3 (0.57) | HRH3HRH1HRH2USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221607-A1 | Piperazine Derivatives | M'S SCIENCE CORPORATION (JP) | 2009-09-03 | — | — | US | claimed |
| EP-1988902-B1 | PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2011-11-23 | — | — | EP | disclosed |
| US-20090221607-A1 | Piperazine Derivatives | M'S SCIENCE CORPORATION (JP) | 2009-09-03 | — | — | US | disclosed |
| EP-1988902-A4 | PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2009-05-06 | — | — | EP | disclosed |
| EP-1988902-A2 | PIPERAZINE DERIVATIVES | M's Science Corporation (JP) | 2008-11-12 | — | — | EP | disclosed |
| WO-2007097871-A2 | PIPERAZINE DERIVATIVES | M'S SCIENCE CORPORATION (JP) | 2007-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221607-A1 | Piperazine Derivatives | SIGMAR1, OPRL1, OPRK1 | LTA4H 2891/4885HRH3 295/4885KCNA5 555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.