Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ESRRG | P62508 | 1/20 | 0.40 |
| ▸ | PANK3 | Q9H999 | 3/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26498519 | 0.88 | ALDH1A1 (0.45) | RORCALDH1A1L3MBTL1MAPTMAPK1 | |
| SCHEMBL17660589 | 0.86 | L3MBTL1 (0.48) | ALDH1A1L3MBTL1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL10169300 | 0.85 | KMT2A (0.53) | L3MBTL1KDM4EKMT2AKDM2BL3MBTL3 | |
| SCHEMBL10169301 | 0.82 | KDM2B (0.53) | L3MBTL1KDM4EKMT2AKDM2BL3MBTL3 | |
| SCHEMBL21026598 | 0.82 | SIGMAR1 (0.53) | L3MBTL1KMT2AKDM2BL3MBTL3HRH3 | |
| SCHEMBL17660576 | 0.82 | NOTUM (0.47) | RORCALDH1A1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL12005505 | 0.81 | MAPT (0.52) | RORCALDH1A1L3MBTL1MAPTMAPK1 | |
| SCHEMBL16440141 | 0.81 | AKR1C3 (0.49) | RORCALDH1A1L3MBTL1MAPTMAPK1 | |
| SCHEMBL20457835 | 0.81 | CHRM1 (0.43) | ALDH1A1MAPTSMN1; SMN2KDM4EGAA | |
| SCHEMBL14923973 | 0.81 | SIGMAR1 (0.55) | L3MBTL1KMT2AKDM2BL3MBTL3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190016717-A1 | TANK-BINDING KINASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. | 2019-01-17 | — | — | US | disclosed |
| US-10040781-B2 | Tank-binding kinase inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2018-08-07 | — | — | US | disclosed |
| US-10040781-B2 | Tank-binding kinase inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2018-08-07 | — | — | US | disclosed |
| US-10005774-B2 | Syk inhibitors | GILEAD SCIENCES, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-20160096827-A1 | TANK-BINDING KINASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2016-04-07 | — | — | US | disclosed |
| US-20150344473-A1 | TANK-BINDING KINASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2015-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344473-A1 | TANK-BINDING KINASE INHIBITOR COMPOUNDS | TBKBP1, TNKS1BP1, TNKS | RORC 2768/4885ALDH1A1 4260/4885L3MBTL1 806/4885 |
| US-10040781-B2 | Tank-binding kinase inhibitor compounds | TBKBP1, TNKS1BP1, TNKS | RORC 2768/4885ALDH1A1 4260/4885L3MBTL1 806/4885 |
| US-20190016717-A1 | TANK-BINDING KINASE INHIBITOR COMPOUNDS | TBKBP1, TNKS1BP1, TNKS | RORC 2768/4885ALDH1A1 4260/4885L3MBTL1 806/4885 |
| US-20160096827-A1 | TANK-BINDING KINASE INHIBITOR COMPOUNDS | TBKBP1, TNKS1BP1, TNKS | RORC 2768/4885ALDH1A1 4260/4885L3MBTL1 806/4885 |
| US-10005774-B2 | Syk inhibitors | SYK, BTK, LYN | RORC 1051/4885ALDH1A1 4181/4885L3MBTL1 2129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.