Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26484667 | 0.92 | SMN1; SMN2 (0.46) | ALDH1A1ABCB1HTR1AADRA1DADRA1A | |
| SCHEMBL26406701 | 0.89 | ALDH1A1 (0.42) | ALDH1A1ABCB1HTR1AADRA1DADRA1A | |
| SCHEMBL17660614 | 0.88 | CCR4 (0.44) | ALDH1A1ABCB1ALDH1A3SMN1; SMN2KDM4E | |
| SCHEMBL17660577 | 0.85 | DRD2 (0.43) | ALDH1A1HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL16440170 | 0.83 | ALDH1A1 (0.56) | ALDH1A1ABCB1HTR1AADRA1DADRA1A | |
| SCHEMBL17660618 | 0.83 | KDM2B (0.46) | ALDH1A1ALDH1A3DRD3KDM2B | |
| SCHEMBL17660603 | 0.83 | KDM2B (0.48) | ALDH1A1ADRA1DADRA1AADRA1BKDM2B | |
| SCHEMBL26484765 | 0.83 | ALDH1A1 (0.47) | ALDH1A1HTR1AALDH1A3SMN1; SMN2HTT | |
| SCHEMBL20458023 | 0.83 | KDM2B (0.47) | ALDH1A1DRD3SMN1; SMN2KDM2BKDM4E | |
| SCHEMBL8343748 | 0.82 | ALDH1A1 (0.58) | ALDH1A1ALDH1A3DRD2DRD3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150344473-A1 | TANK-BINDING KINASE INHIBITOR COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2015-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344473-A1 | TANK-BINDING KINASE INHIBITOR COMPOUNDS | TBKBP1, TNKS1BP1, TNKS | ALDH1A1 4260/4885ABCB1 3231/4885HTR1A 4440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.