Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | TYR | P14679 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1883462 | 0.86 | CYP1A2 (0.61) | KMT2ACYP1A2ALDH1A1TP53TYR | |
| SCHEMBL4524236 | 0.84 | KMT2A (0.63) | KMT2ACYP1A2ALDH1A1TP53TYR | |
| SCHEMBL3430494 | 0.82 | MEN1 (0.51) | KMT2AALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL4047674 | 0.80 | KMT2A (0.76) | KMT2ACYP1A2ALDH1A1TP53TYR | |
| SCHEMBL15652254 | 0.76 | MEN1 (0.53) | KMT2AALDH1A1HSD17B10MEN1TOP2A | |
| SCHEMBL29838519 | 0.76 | IDO1 (0.68) | KMT2ACYP1A2ALDH1A1TP53TYR | |
| SCHEMBL147446 | 0.76 | IDO1 (0.68) | KMT2ACYP1A2ALDH1A1TP53TYR | |
| SCHEMBL4704985 | 0.75 | LMNA (0.48) | KMT2ACYP1A2ALDH1A1GRIN2DGRIN3B | |
| SCHEMBL5141326 | 0.75 | MEN1 (0.51) | KMT2ACYP1A2ALDH1A1MEN1KDM4E | |
| SCHEMBL5141327 | 0.75 | MEN1 (0.51) | KMT2ACYP1A2ALDH1A1MEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154980-B1 | TETRAHYDROTRIAZOLOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES | CHIESI FARM SPA (IT) | 2021-08-04 | — | — | EP | disclosed |
| EP-3154980-B1 | TETRAHYDROTRIAZOLOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES | CHIESI FARM SPA (IT) | 2021-08-04 | — | — | EP | disclosed |
| EP-3154980-A1 | TETRAHYDROTRIAZOLOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES | Chiesi Farmaceutici S.p.A. (IT) | 2017-04-19 | — | — | EP | disclosed |
| CN-106459065-A | Tetrahydrotriazolopyrimidine derivatives, pharmaceutical compositions containing the same and uses | 奇斯药制品公司 | 2017-02-22 | — | — | CN | disclosed |
| US-9487528-B2 | Compounds | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-11-08 | — | — | US | disclosed |
| US-9487528-B2 | Compounds | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-11-08 | — | — | US | disclosed |
| US-9487528-B2 | Compounds | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-11-08 | — | — | US | disclosed |
| WO-2015189362-A1 | TETRAHYDROTRIAZOLOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-17 | — | — | WO | disclosed |
| WO-2015189362-A1 | TETRAHYDROTRIAZOLOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-17 | — | — | WO | disclosed |
| US-20150353561-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-10 | — | — | US | disclosed |
| US-20150353561-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-10 | — | — | US | disclosed |
| US-20150353561-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353561-A1 | NOVEL COMPOUNDS | SERPINB1, ELANE, MPO | KMT2A 4016/4885CYP1A2 1669/4885ALDH1A1 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.